Intracellular delivery of a catalytic organometallic complex

A homogeneous carbene-based palladium catalyst was conjugated to a cell-penetrating peptide, allowing intracellular delivery of catalytically active Pd complexes that demonstrated bioorthogonal activation of a profluorophore within prostate cancer cells.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (50), p.6712-6715
Main Authors: Indrigo, Eugenio, Clavadetscher, Jessica, Chankeshwara, Sunay V, Megia-Fernandez, Alicia, Lilienkampf, Annamaria, Bradley, Mark
Format: Article
Language:English
Subjects:
Activation
Cancer
Catalysis
Catalysts
Metalorganic compounds
Palladium
Peptides
Prostate
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Description
Summary:A homogeneous carbene-based palladium catalyst was conjugated to a cell-penetrating peptide, allowing intracellular delivery of catalytically active Pd complexes that demonstrated bioorthogonal activation of a profluorophore within prostate cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc02988h