POCT PT INR — Is it adequate for patient care? A comparison of the Roche Coaguchek XS vs. Stago Star vs. Siemens BCS in patients routinely seen in an anticoagulation clinic

In this study we examined the difference in patient INR values as measured by the POCT CoaguChek XS device and central laboratory Stago Evolution and Siemens BCS XP analyzers. This study composed of 100 warfarin therapy patients and 20 coagulation normal subjects, showed that the difference between...

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Bibliographic Details
Published in:Clinica chimica acta 2017-09, Vol.472, p.139-145
Main Authors: Baker, Wendy S., Albright, Kathleen J., Berman, Megan, Spratt, Heidi, Mann, Peggy A., Unabia, Jaime, Petersen, John R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Animals
Anticoagulants - therapeutic use
Anticoagulation
CoaguChek XS
Female
Humans
INR
International Normalized Ratio
Laboratories
Middle Aged
Patient Care - standards
POCT
Point of care testing
Point-of-Care Systems - standards
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Summary:In this study we examined the difference in patient INR values as measured by the POCT CoaguChek XS device and central laboratory Stago Evolution and Siemens BCS XP analyzers. This study composed of 100 warfarin therapy patients and 20 coagulation normal subjects, showed that the difference between the POCT and clinical laboratory values increased with increasing INR and was exacerbated by the use of different thromboplastin reagents by the POCT and central lab. The CoaguChek XS and on-site Stago analyzers which used human recombinant (ISI=1.01) and rabbit brain thromboplastin (ISI=1.25), respectively, showed reasonable agreement for INR
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2017.07.027