Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis in Mongolia: The first report of the full genome sequence of a novel genotype 1 hepatitis E virus strain

In January 2012, Mongolia started a hepatitis A vaccination program, which has not yet been evaluated. The first occurrence of autochthonous acute hepatitis E in 2013, caused by genotype 4 hepatitis E virus (HEV), suggests the need for a routine study to monitor its prevalence. One hundred fifty‐fou...

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Bibliographic Details
Published in:Journal of medical virology 2018-01, Vol.90 (1), p.84-92
Main Authors: Tsatsralt‐Od, Bira, Primadharsini, Putu Prathiwi, Nishizawa, Tsutomu, Ohnishi, Hiroshi, Nagashima, Shigeo, Takahashi, Masaharu, Jirintai, Suljid, Nyamkhuu, Dulmaa, Okamoto, Hiroaki
Format: Article
Language:English
Subjects:
Acute Disease
acute hepatitis A
acute hepatitis E
Adult
Female
Genome, Viral
Genomes
Genotype
Genotype & phenotype
genotype 1 HEV
Hepatitis
Hepatitis A
Hepatitis A - blood
Hepatitis A - epidemiology
Hepatitis A - immunology
Hepatitis A - virology
Hepatitis A virus - genetics
Hepatitis A virus - immunology
Hepatitis Antibodies - blood
Hepatitis E - blood
Hepatitis E - epidemiology
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - immunology
Humans
Immunization
Male
Mongolia
Mongolia - epidemiology
novel HEV subtype
Nucleotide sequence
Patients
Phylogeny
Prevalence
RNA, Viral - genetics
Vaccination
Virology
Viruses
Whole Genome Sequencing
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Description
Summary:In January 2012, Mongolia started a hepatitis A vaccination program, which has not yet been evaluated. The first occurrence of autochthonous acute hepatitis E in 2013, caused by genotype 4 hepatitis E virus (HEV), suggests the need for a routine study to monitor its prevalence. One hundred fifty‐four consecutive patients who were clinically diagnosed with acute hepatitis between 2014 and 2015 in Ulaanbaatar, Mongolia were studied. By serological and molecular testing followed by sequencing and phylogenetic analysis, only one patient (0.6%) was diagnosed with acute hepatitis A, caused by genotype IA hepatitis A virus (HAV), and 32 (20.8%) patients were diagnosed with acute hepatitis E, caused by genotype 1 HEV. The 32 HEV isolates obtained in this study shared 99.5‐100% nucleotide identity and were grouped into a cluster separated from those of subtypes 1a to 1f. Upon comparison of p‐distances over the entire genome, the distances between one representative HEV isolate (MNE15‐072) and 1a‐1f strains were 0.071‐0.137, while those between 1b and 1c were 0.062‐0.070. In conclusion, the prevalence of acute hepatitis A has decreased in Mongolia since the start of the vaccination program, while the monophyletic genotype 1 HEV strain of a probably novel subtype has been prevalent.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24907