Hypomethylation‐mediated H19 overexpression increases the risk of disease evolution through the association with BCR‐ABL transcript in chronic myeloid leukemia

Previous study has revealed that H19 expression is required for efficient tumor growth induced by BCR‐ABL in chronic myeloid leukemia (CML). Herein, we further determined H19 expression and its clinical implication in patients with CML. H19 expression and methylation were detected by real‐time quant...

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Bibliographic Details
Published in:Journal of cellular physiology 2018-03, Vol.233 (3), p.2444-2450
Main Authors: Zhou, Jing‐dong, Lin, Jiang, Zhang, Ting‐juan, Ma, Ji‐chun, Li, Xi‐xi, Wen, Xiang‐mei, Guo, Hong, Xu, Zi‐jun, Deng, Zhao‐qun, Zhang, Wei, Qian, Jun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
BCR-ABL protein
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Blast crisis
Case-Control Studies
Chronic myeloid leukemia
CML
Demethylation
Disease Progression
DNA Methylation
Drugs
Epigenesis, Genetic
expression
Female
Fusion protein
Fusion Proteins, bcr-abl - genetics
Fusion Proteins, bcr-abl - metabolism
Gene Expression Regulation, Leukemic
Genomic imprinting
H19
Health risks
Humans
K562 Cells
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Leukocytes
Male
Methylation
Middle Aged
Myeloid leukemia
Patients
Protein-tyrosine kinase
Real time
Remission
Risk assessment
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcription
Transcription, Genetic
Tyrosine
Up-Regulation
Young Adult
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Summary:Previous study has revealed that H19 expression is required for efficient tumor growth induced by BCR‐ABL in chronic myeloid leukemia (CML). Herein, we further determined H19 expression and its clinical implication in patients with CML. H19 expression and methylation were detected by real‐time quantitative PCR and real‐time quantitative methylation‐specific PCR, and then clinical implication of H19 expression was further analyzed. H19 expression was significantly up‐regulated in CML patients (p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.26119