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Tectal corticotropin-releasing factor (CRF) neurons respond to fasting and a reactive stressor in the African Clawed Frog, Xenopus laevis
•Exposure to a reactive stressor decreases food intake.•CRF content is greater in the tectum than brainstem and telencephalon in X. laevis.•Tectal CRF neurons are activated during a reactive stressor.•Tectal CRF content is reduced after food deprivation.•Tectal CRF and CRFR1 transcript abundance are...
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Published in: | General and comparative endocrinology 2018-03, Vol.258, p.91-98 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Exposure to a reactive stressor decreases food intake.•CRF content is greater in the tectum than brainstem and telencephalon in X. laevis.•Tectal CRF neurons are activated during a reactive stressor.•Tectal CRF content is reduced after food deprivation.•Tectal CRF and CRFR1 transcript abundance are unchanged after food deprivation.
It is well established that hypothalamic neurons producing the peptide corticotropin-releasing factor (CRF) play a key role in stress adaptation, including reduction of food intake when a threat or stressor is present. We have previously reported on the presence of an intrinsic CRF signaling system within the optic tectum (OT), a brain area that plays a key role in visually guided prey capture/predator avoidance decisions. To better understand the potential role of tectal CRF neurons in regulating adaptive behavior and energy balance during stress we examined evidence for modulation of tectal CRF neuronal activity after stressor exposure and food deprivation in the African clawed frog Xenopus laevis. We tested two predictions, 1) that exposure to categorically distinct stressors (ether vapors and shaking) will reduce food intake and modulate the activity of tectal CRF cells, and 2) that food deprivation will modulate the activity of tectal CRF cells. Exposure to ether increased tectal content of CRF and CRF transcript, but lowed CRFR1 transcript abundance. Two weeks of food deprivation reduced total fat stores in frogs and decreased tectal content of CRF content while having no effect on CRF and CRFR1 transcript abundance. Our data are consistent with a role for tectal CRF neurons in modulating food intake in response to certain stressors. |
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ISSN: | 0016-6480 1095-6840 |
DOI: | 10.1016/j.ygcen.2017.07.029 |