Association between S100B gene polymorphisms and hand, foot and mouth disease caused by enterovirus 71 infection

To investigate the association between rs9722 polymorphisms in the S100B gene and hand, foot and mouth disease (HFMD) caused by enterovirus 71. A total of 124 HFMD children with enterovirus 71 infection were enrolled as subjects, and 56 healthy children were enrolled as control group. The rs9722 pol...

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Published in:Zhongguo dang dai er ke za zhi 2017-08, Vol.19 (8), p.904-907
Main Authors: Li, Jing, Shan, Ruo-Bing, Liu, Rui-Hai, Xu, Ying-Jun, Qu, Ni-Yan, Pan, Gui-Mei, Zhang, Na, Yang, Na, Chen, Zhen-Zhen, Zhang, Wen-Xiang, Li, Zi-Pu
Format: Article
Language:Chinese
Subjects:
Child, Preschool
Enterovirus A, Human
Enterovirus Infections - complications
Female
Genotype
Hand, Foot and Mouth Disease - etiology
Hand, Foot and Mouth Disease - genetics
Humans
Infant
Male
Polymorphism, Genetic
S100 Calcium Binding Protein beta Subunit - genetics
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Summary:To investigate the association between rs9722 polymorphisms in the S100B gene and hand, foot and mouth disease (HFMD) caused by enterovirus 71. A total of 124 HFMD children with enterovirus 71 infection were enrolled as subjects, and 56 healthy children were enrolled as control group. The rs9722 polymorphisms in the S100B gene were detected for both groups, and the serum level of S100B protein was measured for 74 HFMD children. The rs9722 locus of the S100B gene had three genotypes, CC, CT, and TT, and the genotype frequencies were in accordance with Hardy-Weinberg equilibrium. Compared with the control group, the HFMD group had significant increases in the frequencies of TT genotype and T allele (P
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2017.08.011