Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India

Abstract Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed de...

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Bibliographic Details
Published in:Journal of neuroimmunology 2017-09, Vol.310, p.8-13
Main Authors: Kumar, Mahesh M, Venkataswamy, Manjunatha M, Sathyanarayanan, Gopinath, Thippeswamy, Harish, Chandra, Prabha S, Mani, Reeta S
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Cytokines - metabolism
Dendritic Cells - metabolism
Dendritic Cells - pathology
Female
Flow Cytometry
Hospitals, Psychiatric - statistics & numerical data
Humans
Immune System Diseases - etiology
Immune System Diseases - pathology
Immunophenotyping
India - epidemiology
Killer Cells, Natural - metabolism
Killer Cells, Natural - pathology
Monocytes - metabolism
Monocytes - pathology
Neurology
Postpartum Period - immunology
Psychotic Disorders - complications
T-Lymphocyte Subsets - metabolism
T-Lymphocyte Subsets - pathology
Tertiary Healthcare
Young Adult
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Summary:Abstract Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T cells, while activated CD8 and memory regulatory T cells (Tregs) were increased in women with PP as against healthy controls. The CD14− CD16+ non-classical monocytes, CD11c + myeloid DCs and cytotoxic CD56dim CD16+ were reduced, while CD56brt CD16+/− regulatory NK cells were elevated in women with PP. The variations in immune cell subsets highlight the generalized immune dysregulation in PP.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2017.06.002