Vitiligo: Mechanistic insights lead to novel treatments

Vitiligo is an autoimmune disease of the skin characterized by patchy depigmentation. Current treatments are moderately effective at reversing disease by suppressing autoimmune inflammation in the skin and promoting melanocyte regeneration. Recent basic and translational research studies have signif...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-09, Vol.140 (3), p.654-662
Main Authors: Frisoli, Michael L., Harris, John E.
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Chemokines
Clinical trials
CXCL10
CXCL9
CXCR3
Disease
Gene expression
Hair
Human subjects
Humans
IFN-γ
Immunity, Innate
inflammasome
innate immunity
Interferon-gamma - immunology
Interleukin-17 - immunology
Kinases
Light therapy
Lymphocytes
Lymphocytes - immunology
melanocyte
Melanocytes - physiology
NLRP1
NLRP3
Pathogenesis
regeneration
regulation
repigmentation
resident memory
Skin
Skin diseases
Stem cells
stress
Studies
T cell
treatment
Tumor necrosis factor-TNF
Vitiligo
Vitiligo - immunology
Vitiligo - therapy
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Description
Summary:Vitiligo is an autoimmune disease of the skin characterized by patchy depigmentation. Current treatments are moderately effective at reversing disease by suppressing autoimmune inflammation in the skin and promoting melanocyte regeneration. Recent basic and translational research studies have significantly improved our understanding of disease pathogenesis, which is now leading to emerging treatment strategies based on targeted therapy. Here we discuss important clinical characteristics of vitiligo, current therapies and their limitations, advances in understanding disease pathogenesis, emerging targeted treatments, and strategies to optimize clinical trials to efficiently and effectively test these new treatments.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.07.011