Do trichothecenes reduce viability of circulating blood cells and modify haemostasis parameters?

This manuscript describes the results of experiments conducted using human blood cells to determine the ability of T-2 toxin and DON to cause changes in clotting time, platelet aggregation, red blood cell haemolysis, RBC glucose content, lactate release, glutathione depletion, as well as white blood...

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Bibliographic Details
Published in:Mycopathologia (1975) 2003-01, Vol.156 (4), p.349-356
Main Authors: Froquet, R, Arnold, F, Batina, P, Parent-Massin, D
Format: Article
Language:English
Subjects:
Anemia
Biological and medical sciences
Blood
blood coagulation
Blood Glucose - metabolism
Blood platelets
Bone marrow
cell aggregates
cytotoxicity
deoxynivalenol
erythrocytes
Erythrocytes - drug effects
Fetal Blood - metabolism
Fundamental and applied biological sciences. Psychology
glucose
glutathione
Glutathione - blood
Hematology
hematopoiesis
Hematopoiesis - drug effects
Hemoglobins - metabolism
hemolysis
Hemorrhage
Humans
Infectious diseases
lactic acid
Lactic Acid - blood
Leukocyte Count
Leukocytes
Leukocytes - drug effects
Leukopenia
Medical sciences
Microbiology
Mycology
Mycoses
Partial Thromboplastin Time
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Platelet Aggregation - drug effects
Platelet Aggregation - physiology
Prothrombin Time
Solvents
T-2 toxin
T-2 Toxin - pharmacology
Thrombin Time
Thrombocytopenia
trichothecenes
Trichothecenes - pharmacology
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Summary:This manuscript describes the results of experiments conducted using human blood cells to determine the ability of T-2 toxin and DON to cause changes in clotting time, platelet aggregation, red blood cell haemolysis, RBC glucose content, lactate release, glutathione depletion, as well as white blood cell viability. In vitro results showed that haemostasis parameters and erythrocytes were not affected at concentrations able to induce inhibition of haematopoietic progenitor proliferation. In the presence of 10(-8) M and 10(-6) M T-2, the leucocyte number decreased at 24 h by 30% and 50% respectively. A 50% decrease in leucocyte number was observed for 10(-5) M DON. Results were compared with haematopoietic progenitor sensitivities. Due to the differences in sensitivities between mature blood cells and haematopoietic progenitors, haematological problems associated with trichothecene intoxication could be attributed to haematopoiesis inhibition.
ISSN:0301-486X
1573-0832
DOI:10.1023/B:MYCO.0000003606.13934.74