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Manganese Distribution in the Brain and Neurobehavioral Changes Following Inhalation Exposure of Rats to Three Chemical Forms of Manganese
The central nervous system is an important target for manganese (Mn) intoxication in humans; it may cause neurological symptoms similar to Parkinson’s disease. Manganese compounds emitted from the tailpipe of vehicles using methylcyclopentadienyl manganese tricarbonyl (MMT) are primarily Mn phosphat...
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| Published in: | Neurotoxicology (Park Forest South) 2004-03, Vol.25 (3), p.433-441 |
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| container_start_page | 433 |
| container_title | Neurotoxicology (Park Forest South) |
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| creator | Normandin, Louise Ann Beaupré, Linda Salehi, Fariba St.-Pierre, Annie Kennedy, Greg Mergler, Donna Butterworth, Roger F Philippe, Suzanne Zayed, Joseph |
| description | The central nervous system is an important target for manganese (Mn) intoxication in humans; it may cause neurological symptoms similar to Parkinson’s disease. Manganese compounds emitted from the tailpipe of vehicles using methylcyclopentadienyl manganese tricarbonyl (MMT) are primarily Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. The purpose of this study is to compare the patterns of Mn distribution in various brain regions (olfactory bulb, frontal parietal cortex, globus pallidus, striatum and cerebellum) and other tissues (lung, liver, kidney, testis) and the neurobehavioral damage following inhalation exposure of rats to three Mn species. Rats (
n=15
rats per Mn species) were exposed 6
h per day, 5 days per week for 13 consecutive weeks to metallic Mn, Mn phosphate or Mn phosphate/sulfate mixture at about 3000
μg
m
−3 and compared to controls. At the end of the exposure period, spontaneous motor activity was measured for 36
h using a computerized autotrack system. Mn in tissues was determined by instrumental neutron activation analysis (INAA). The Mn concentrations in the brain were significantly higher in rats exposed to Mn phosphate and Mn phosphate/sulfate mixture than in control rats or rats exposed to metallic Mn. Exposure to Mn phosphate/sulfate mixture caused a decrease in the total ambulatory count related to locomotor activity. Our results confirm that Mn species and solubility have an influence on the brain distribution of Mn in rats. |
| doi_str_mv | 10.1016/j.neuro.2003.10.001 |
| format | article |
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n=15
rats per Mn species) were exposed 6
h per day, 5 days per week for 13 consecutive weeks to metallic Mn, Mn phosphate or Mn phosphate/sulfate mixture at about 3000
μg
m
−3 and compared to controls. At the end of the exposure period, spontaneous motor activity was measured for 36
h using a computerized autotrack system. Mn in tissues was determined by instrumental neutron activation analysis (INAA). The Mn concentrations in the brain were significantly higher in rats exposed to Mn phosphate and Mn phosphate/sulfate mixture than in control rats or rats exposed to metallic Mn. Exposure to Mn phosphate/sulfate mixture caused a decrease in the total ambulatory count related to locomotor activity. Our results confirm that Mn species and solubility have an influence on the brain distribution of Mn in rats.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2003.10.001</identifier><identifier>PMID: 15019306</identifier><language>eng</language><publisher>Orlando, FL: Elsevier B.V</publisher><subject>Animals ; Bioaccumulation ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Chemical and industrial products toxicology. Toxic occupational diseases ; Inhalation ; Inhalation Exposure - adverse effects ; Locomotor activity ; Male ; Manganese - chemistry ; Manganese - metabolism ; Manganese - pharmacology ; Manganese Compounds - chemistry ; Manganese Compounds - metabolism ; Manganese Compounds - pharmacology ; Manganese phosphate ; Manganese sulfate ; Medical sciences ; Metallic manganese ; Metals and various inorganic compounds ; Motor Activity - drug effects ; Motor Activity - physiology ; Organometallic Compounds - chemistry ; Organometallic Compounds - metabolism ; Organometallic Compounds - pharmacology ; Rats ; Rats, Sprague-Dawley ; Sulfates - chemistry ; Sulfates - metabolism ; Sulfates - pharmacology ; Toxicology</subject><ispartof>Neurotoxicology (Park Forest South), 2004-03, Vol.25 (3), p.433-441</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-deae400c2eb64bb3514f7e6b2c4395ab696cf433155c443771f7b47a0bba14d93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15543815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15019306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Normandin, Louise</creatorcontrib><creatorcontrib>Ann Beaupré, Linda</creatorcontrib><creatorcontrib>Salehi, Fariba</creatorcontrib><creatorcontrib>St.-Pierre, Annie</creatorcontrib><creatorcontrib>Kennedy, Greg</creatorcontrib><creatorcontrib>Mergler, Donna</creatorcontrib><creatorcontrib>Butterworth, Roger F</creatorcontrib><creatorcontrib>Philippe, Suzanne</creatorcontrib><creatorcontrib>Zayed, Joseph</creatorcontrib><title>Manganese Distribution in the Brain and Neurobehavioral Changes Following Inhalation Exposure of Rats to Three Chemical Forms of Manganese</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>The central nervous system is an important target for manganese (Mn) intoxication in humans; it may cause neurological symptoms similar to Parkinson’s disease. Manganese compounds emitted from the tailpipe of vehicles using methylcyclopentadienyl manganese tricarbonyl (MMT) are primarily Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. The purpose of this study is to compare the patterns of Mn distribution in various brain regions (olfactory bulb, frontal parietal cortex, globus pallidus, striatum and cerebellum) and other tissues (lung, liver, kidney, testis) and the neurobehavioral damage following inhalation exposure of rats to three Mn species. Rats (
n=15
rats per Mn species) were exposed 6
h per day, 5 days per week for 13 consecutive weeks to metallic Mn, Mn phosphate or Mn phosphate/sulfate mixture at about 3000
μg
m
−3 and compared to controls. At the end of the exposure period, spontaneous motor activity was measured for 36
h using a computerized autotrack system. Mn in tissues was determined by instrumental neutron activation analysis (INAA). The Mn concentrations in the brain were significantly higher in rats exposed to Mn phosphate and Mn phosphate/sulfate mixture than in control rats or rats exposed to metallic Mn. Exposure to Mn phosphate/sulfate mixture caused a decrease in the total ambulatory count related to locomotor activity. Our results confirm that Mn species and solubility have an influence on the brain distribution of Mn in rats.</description><subject>Animals</subject><subject>Bioaccumulation</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Inhalation</subject><subject>Inhalation Exposure - adverse effects</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Manganese - chemistry</subject><subject>Manganese - metabolism</subject><subject>Manganese - pharmacology</subject><subject>Manganese Compounds - chemistry</subject><subject>Manganese Compounds - metabolism</subject><subject>Manganese Compounds - pharmacology</subject><subject>Manganese phosphate</subject><subject>Manganese sulfate</subject><subject>Medical sciences</subject><subject>Metallic manganese</subject><subject>Metals and various inorganic compounds</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - metabolism</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sulfates - chemistry</subject><subject>Sulfates - metabolism</subject><subject>Sulfates - pharmacology</subject><subject>Toxicology</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EokPhCZCQN7DL4Bs7fwsWMHTaSgUkVCR2lu3cNB4l9mAnBV6Bp8bpjCirrmxdf-f66BxCXgJbA4Py7W7tcA5-nTPG02TNGDwiK6irPGsqgMdklSjIauDfT8izGHcJKKqyeUpOoGDQcFauyJ9Pyt0ohxHpRxunYPU8We-odXTqkX4IKt2Ua-nn5S-Nvbq1PqiBbvokxEi3fhj8T-tu6KXr1aDu1Ge_9j7OAanv6Fc1RTp5et0HxCTD0Zqk3_owxuX9n4Hn5Emnhogvjucp-bY9u95cZFdfzi83768yI-p8ylpUKBgzOepSaM0LEF2Fpc6N4E2hdNmUphOcQ1EYIXhVQVdpUSmmtQLRNvyUvDns3Qf_Y8Y4ydFGg8OQXPg5Smjysi6bBeQH0AQfY8BO7oMdVfgtgcmlArmTdxXIpYJlmBJOqlfH9bMesb3XHDNPwOsjoGJKogvKGRv_4wrBaygS9-7AYQrj1mKQ0Vh0Blsb0Eyy9fZBI38BF1Onnw</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Normandin, Louise</creator><creator>Ann Beaupré, Linda</creator><creator>Salehi, Fariba</creator><creator>St.-Pierre, Annie</creator><creator>Kennedy, Greg</creator><creator>Mergler, Donna</creator><creator>Butterworth, Roger F</creator><creator>Philippe, Suzanne</creator><creator>Zayed, Joseph</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20040301</creationdate><title>Manganese Distribution in the Brain and Neurobehavioral Changes Following Inhalation Exposure of Rats to Three Chemical Forms of Manganese</title><author>Normandin, Louise ; Ann Beaupré, Linda ; Salehi, Fariba ; St.-Pierre, Annie ; Kennedy, Greg ; Mergler, Donna ; Butterworth, Roger F ; Philippe, Suzanne ; Zayed, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-deae400c2eb64bb3514f7e6b2c4395ab696cf433155c443771f7b47a0bba14d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Bioaccumulation</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Inhalation</topic><topic>Inhalation Exposure - adverse effects</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Manganese - chemistry</topic><topic>Manganese - metabolism</topic><topic>Manganese - pharmacology</topic><topic>Manganese Compounds - chemistry</topic><topic>Manganese Compounds - metabolism</topic><topic>Manganese Compounds - pharmacology</topic><topic>Manganese phosphate</topic><topic>Manganese sulfate</topic><topic>Medical sciences</topic><topic>Metallic manganese</topic><topic>Metals and various inorganic compounds</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - metabolism</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sulfates - chemistry</topic><topic>Sulfates - metabolism</topic><topic>Sulfates - pharmacology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Normandin, Louise</creatorcontrib><creatorcontrib>Ann Beaupré, Linda</creatorcontrib><creatorcontrib>Salehi, Fariba</creatorcontrib><creatorcontrib>St.-Pierre, Annie</creatorcontrib><creatorcontrib>Kennedy, Greg</creatorcontrib><creatorcontrib>Mergler, Donna</creatorcontrib><creatorcontrib>Butterworth, Roger F</creatorcontrib><creatorcontrib>Philippe, Suzanne</creatorcontrib><creatorcontrib>Zayed, Joseph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Normandin, Louise</au><au>Ann Beaupré, Linda</au><au>Salehi, Fariba</au><au>St.-Pierre, Annie</au><au>Kennedy, Greg</au><au>Mergler, Donna</au><au>Butterworth, Roger F</au><au>Philippe, Suzanne</au><au>Zayed, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manganese Distribution in the Brain and Neurobehavioral Changes Following Inhalation Exposure of Rats to Three Chemical Forms of Manganese</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>25</volume><issue>3</issue><spage>433</spage><epage>441</epage><pages>433-441</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>The central nervous system is an important target for manganese (Mn) intoxication in humans; it may cause neurological symptoms similar to Parkinson’s disease. Manganese compounds emitted from the tailpipe of vehicles using methylcyclopentadienyl manganese tricarbonyl (MMT) are primarily Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. The purpose of this study is to compare the patterns of Mn distribution in various brain regions (olfactory bulb, frontal parietal cortex, globus pallidus, striatum and cerebellum) and other tissues (lung, liver, kidney, testis) and the neurobehavioral damage following inhalation exposure of rats to three Mn species. Rats (
n=15
rats per Mn species) were exposed 6
h per day, 5 days per week for 13 consecutive weeks to metallic Mn, Mn phosphate or Mn phosphate/sulfate mixture at about 3000
μg
m
−3 and compared to controls. At the end of the exposure period, spontaneous motor activity was measured for 36
h using a computerized autotrack system. Mn in tissues was determined by instrumental neutron activation analysis (INAA). The Mn concentrations in the brain were significantly higher in rats exposed to Mn phosphate and Mn phosphate/sulfate mixture than in control rats or rats exposed to metallic Mn. Exposure to Mn phosphate/sulfate mixture caused a decrease in the total ambulatory count related to locomotor activity. Our results confirm that Mn species and solubility have an influence on the brain distribution of Mn in rats.</abstract><cop>Orlando, FL</cop><pub>Elsevier B.V</pub><pmid>15019306</pmid><doi>10.1016/j.neuro.2003.10.001</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0161-813X |
| ispartof | Neurotoxicology (Park Forest South), 2004-03, Vol.25 (3), p.433-441 |
| issn | 0161-813X 1872-9711 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Bioaccumulation Biological and medical sciences Brain - drug effects Brain - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Inhalation Inhalation Exposure - adverse effects Locomotor activity Male Manganese - chemistry Manganese - metabolism Manganese - pharmacology Manganese Compounds - chemistry Manganese Compounds - metabolism Manganese Compounds - pharmacology Manganese phosphate Manganese sulfate Medical sciences Metallic manganese Metals and various inorganic compounds Motor Activity - drug effects Motor Activity - physiology Organometallic Compounds - chemistry Organometallic Compounds - metabolism Organometallic Compounds - pharmacology Rats Rats, Sprague-Dawley Sulfates - chemistry Sulfates - metabolism Sulfates - pharmacology Toxicology |
| title | Manganese Distribution in the Brain and Neurobehavioral Changes Following Inhalation Exposure of Rats to Three Chemical Forms of Manganese |
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