The evaluation of brain perfusion SPECT using an easy Z-score imaging system in the mild cognitive impairment subjects with brain amyloid-β deposition

• Published in: Clinical neurology and neurosurgery 2017-09, Vol.160, p.111-115
• Main Authors: Takemaru, Makoto, Kimura, Noriyuki, Abe, Yoshitake, Goto, Megumi, Matsubara, Etsuro
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Aging; Amnesia - diagnostic imaging; Amnesia - metabolism; Amyloid beta-Peptides - metabolism; Amyloid PET imaging; Aniline Compounds; Automation; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain perfusion SPECT; Cognitive ability; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - metabolism; Computed tomography; Conversion; Data processing; Dementia; Easy Z-score analysis; Education; Emission analysis; Female; Humans; Impairment; Indicators; Male; Medical imaging; Memory; Men; Middle Aged; Mild cognitive impairment; Neuroimaging; Neurology; NMR; Nuclear magnetic resonance; Organotechnetium Compounds; Perfusion; Perfusion Imaging - methods; Perfusion Imaging - standards; Positron emission tomography; Sensitivity and Specificity; Single photon emission computed tomography; Thiazoles; Tomography; Tomography, Emission-Computed, Single-Photon - methods; Tomography, Emission-Computed, Single-Photon - standards; β-Amyloid
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2017.06.018

•Usefulness of eZIS program for predicting brain amyloid deposition.•Abnormal two or three indicators including ratio may reflect PiB-positive.•Normal ratio value may reflect PiB-negative. The analysis of 99mTc-ECD single-photon emission computed tomography (SPECT) images using the easy Z-score imaging system (eZIS) program is useful for the diagnosis of early AD in daily medical practice. However, it remains unclear whether eZIS analysis can identify the amnestic mild cognitive impairment (MCI) subjects with brain amyloid-β deposition. The aim of this study was to evaluate the usefulness of an eZIS analysis for predicting amnestic MCI subjects with brain amyloid β deposition. Twenty-three subjects with MCI (10 men and 13 women, mean age; 74.2 years) underwent brain perfusion SPECT and 11C-Pittsburgh Compound B positron emission tomography (PiB-PET). MCI subjects were divided into PiB-positive and PiB-negative subgroups. SPECT data was analyzed using the Specific Volume of interest Analysis of the eZIS program. Three indicators (severity, extent, and ratio) were calculated automatically and compared between the two subgroups. Five of 12 (41.7%) subjects in the PiB-positive subgroup and three of 11 (27.3%) subjects in the PiB-negative subgroup showed the abnormal value for each indicator. The frequency of subjects with abnormal ratio values was significantly higher in the PiB-positive subgroup compared to the PiB-negative subgroup (p=0.02), whereas that of subjects with abnormal values in severity and extent did not differ among the two subgroups. In particular, all subjects in the PiB-negative subgroup showed normal ratio values. Moreover, the subjects with abnormal values on two indicators, including ratio, or on all three indicators, showed PiB-positive. The analysis of brain perfusion SPECT using an eZIS program cannot identify the amnestic MCI subjects with brain amyloid-β deposition. However, abnormal three indicators or normal ratio values may be helpful SPECT findings for predicting the results of PiB-PET in the amnestic MCI subjects.