High probability and frequency of EGFR mutations in non-small cell lung cancer with brain metastases

• Published in: Journal of neuro-oncology 2017-11, Vol.135 (2), p.413-418
• Main Authors: Ge, Mengxi, Zhuang, Yingjie, Zhou, Xinli, Huang, Ruofan, Liang, Xiaohua, Zhan, Qiong
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Brain cancer; Brain Neoplasms - epidemiology; Brain Neoplasms - genetics; Brain Neoplasms - secondary; Carcinoma, Non-Small-Cell Lung - epidemiology; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Clinical Study; Epidermal growth factor; Epidermal growth factor receptors; Exons; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Incidence; Lung cancer; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Metastases; Metastasis; Middle Aged; Mutation; Neoplasm Metastasis - genetics; Neurology; Non-small cell lung carcinoma; Oncology; Polymerase chain reaction; Prevalence; Receptor, Epidermal Growth Factor - genetics; Retrospective Studies; Squamous cell carcinoma
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1007/s11060-017-2590-x

Lung cancer is the leading cause of cancer death in men and women worldwide. Brain metastasis (BMs) of non-small cell lung cancer (NSCLC) is the most important cause of death. This study aimed to explore the association of epidermal growth factor receptor (EGFR) mutations and BMs in NSCLC. We analyzed 50 NSCLC patients with BMs and 50 match-paired NSCLC patients with no brain metastases (NBMs). The EGFR mutation status of primary lesions was detected using the amplification refractory mutation system polymerase chain reaction. The BMs patients had a higher frequency of EGFR mutations than the NBMs patients (52.0 vs. 22.0% respectively, P