The value of ESWAN in diagnosis and differential diagnosis of prostate cancer: Preliminary study

• Published in: Magnetic resonance imaging 2017-12, Vol.44, p.26-31
• Main Authors: Xin, Jian-Ying, Gao, Shan-Shan, Liu, Jin-Gang, Sun, Cheng-Feng, Han, Yu, Sun, Xi-He, Wang, Xi-Zhen, Wang, Bin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Angiography; Area Under Curve; Benign prostatic hyperplasia; Diagnosis, Computer-Assisted; Diagnosis, Differential; Enhanced T2 star-weighted angiography; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Prostate cancer; Prostatic Hyperplasia - diagnosis; Prostatic Neoplasms - diagnosis; ROC Curve; Sensitivity and Specificity; Susceptibility-weighted imaging
• ISSN: 0730-725X; 1873-5894
• DOI: 10.1016/j.mri.2017.08.002

To evaluate the value of enhanced T2 star-weighted angiography (ESWAN) in diagnosis and differential diagnosis of prostate cancer by comparing the multiple indices of ESWAN in benign prostatic hyperplasia (BPH), prostate cancer (PCa) and the normal peripheral zone (PZ). Traditional MRI and ESWAN were performed on forty-nine clinically-diagnosed PCa patients, sixty BPH patients, and forty-six normal adult males. The ESWAN indices (magnitude value, phase value, R2* value and T2* value) measured on different regions of interest (ROIs) were analyzed. Additionally, receiver operating characteristic (ROC) analysis was performed to obtain the area under the curve (AUC), sensitivity, specificity, and optimal cut-off points of PCa and BPH, PCa and PZ respectively. The magnitude value, phase value, R2* value and T2* value of PZ were 1529.43±254.43, 0.0689±0.1619, 16.57±8.11, 82.75±53.87, respectively; the magnitude value, phase value, R2* value, and T2* value of PCa were 1540.18±338.62, −0.0176±0.0919, 26.93±11.31, and 45.99±17.43, respectively; the magnitude value, phase value, R2* value, and T2* value of BPH were 1579.49±285.28, 0.0209±0.0839, 20.69±3.95, and 51.56±8.90, respectively. Compared with normal PZ, phase value of PCa was lower (t=−3.302, P=0.001), R2* value higher (t=5.326, P=0.000), and T2* value lower (t=−4.570, P=0.000); compared with BPH, phase value of PCa was lower (t=−2.261, P=0.026), R2* value higher (t=3.988, P=0.000), and T2* value lower (t=−2.155, P=0.033). When PCa and PZ were distinguished, the AUC of magnitude value, phase value, R2* value, and T2* value were respectively 0.539 (P=0.510), 0.679 (P=0.0007), 0.811 (P