Aurora kinases link chromosome segregation and cell division to cancer susceptibility

Aurora kinases play critical roles in chromosome segregation and cell division. They are implicated in the centrosome cycle, spindle assembly, chromosome condensation, microtubule–kinetochore attachment, the spindle checkpoint and cytokinesis. Aurora kinases are regulated through phosphorylation, th...

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Bibliographic Details
Published in:Current opinion in genetics & development 2004-02, Vol.14 (1), p.29-36
Main Authors: Meraldi, Patrick, Honda, Reiko, Nigg, Erich A
Format: Article
Language:English
Subjects:
Aurora A protein
Aurora Kinases
Cell Division
Chromosome Segregation - genetics
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Mitosis - genetics
Models, Biological
Neoplasms - genetics
Phosphorylation
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
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Summary:Aurora kinases play critical roles in chromosome segregation and cell division. They are implicated in the centrosome cycle, spindle assembly, chromosome condensation, microtubule–kinetochore attachment, the spindle checkpoint and cytokinesis. Aurora kinases are regulated through phosphorylation, the binding of specific partners and ubiquitin-dependent proteolysis. Several Aurora substrates have been identified and their roles are being elucidated. The deregulation of Aurora kinases impairs spindle assembly, checkpoint function and cell division, causing missegregation of individual chromosomes or polyploidization accompanied by centrosome amplification. Aurora kinases are frequently overexpressed in cancers and the identification of Aurora A as a cancer-susceptibility gene provides a strong link between mitotic errors and carcinogenesis.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2003.11.006