Effect of action potential duration on Tpeak-Tend interval, T-wave area and T-wave amplitude as indices of dispersion of repolarization: Theoretical and simulation study in the rabbit heart

• Published in: Journal of electrocardiology 2017-11, Vol.50 (6), p.919-924
• Main Authors: Arteyeva, Natalia V., Azarov, Jan E.
• Format: Article
• Language: English
• Subjects: Action potential duration; Dispersion of repolarization; T-wave amplitude; T-wave area; Tpeak-Tend interval
• ISSN: 0022-0736; 1532-8430
• DOI: 10.1016/j.jelectrocard.2017.07.001

The aim of the study was to differentiate the effect of dispersion of repolarization (DOR) and action potential duration (APD) on T-wave parameters being considered as indices of DOR, namely, Tpeak-Tend interval, T-wave amplitude and T-wave area. T-wave was simulated in a wide physiological range of DOR and APD using a realistic rabbit model based on experimental data. A simplified mathematical formulation of T-wave formation was conducted. Both the simulations and the mathematical formulation showed that Tpeak-Tend interval and T-wave area are linearly proportional to DOR irrespectively of APD range, while T-wave amplitude is non-linearly proportional to DOR and inversely proportional to the minimal repolarization time, or minimal APD value. Tpeak-Tend interval and T-wave area are the most accurate DOR indices independent of APD. T-wave amplitude can be considered as an index of DOR when the level of APD is taken into account. •Tpeak-Tend interval is equal to dispersion of repolarization irrespectively of APD.•T-wave area is linearly proportional to dispersion of repolarization at any APD.•T-wave amplitude is a function of two variables: dispersion of repolarization and APD.•T-wave amplitude is non-linearly proportional to dispersion of repolarization.•T-wave amplitude is inversely proportional to APD.