Obesity-related glomerulopathy： pathogenesis, pathologic, clinical characteristics and treatment

n light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related giomerulopathy （ORG） is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions...

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Bibliographic Details
Published in:Frontiers of medicine 2017-09, Vol.11 (3), p.340-348
Main Authors: Xu, Tianhua, Sheng, Zitong, Yao, Li
Format: Article
Language:English
Subjects:
clinical characteristics
Glomerulosclerosis, Focal Segmental - etiology
Glomerulosclerosis, Focal Segmental - pathology
Humans
Kidney Diseases - diagnosis
Kidney Diseases - etiology
Kidney Diseases - pathology
Kidney Diseases - therapy
Kidney Glomerulus - pathology
Medicine
Medicine & Public Health
Obesity
Obesity - complications
Obesity - physiopathology
Obesity - therapy
obesity-related glomerulopathy
pathogenesis
pathologic
Review
Risk Factors
Weight control
Weight Loss
临床特点
发病机制
治疗
病理
相关疾病
肥胖
肾素-血管紧张素-醛固酮系统
肾脏病变
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Summary:n light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related giomerulopathy （ORG） is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 （C3） nonspeciflcally deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria （ 〈 3.5 g/d） is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin-angiotensin-aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-017-0570-3