Significance of interferon gamma in the prediction of successful therapy of common warts by intralesional injection of Candida antigen

Background Treatment of common warts remains a continuing challenge for both patients and physicians. Recently, intralesional immunotherapy by different antigens has proved efficacious in the treatment of warts, however, no definite predictive factors for successful therapy have been established. He...

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Bibliographic Details
Published in:International journal of dermatology 2017-10, Vol.56 (10), p.1003-1009
Main Authors: Nofal, Ahmad, Marei, Ayman, Amer, Amin, Amen, Hanaa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens
Antigens, Fungal - adverse effects
Antigens, Fungal - therapeutic use
Blood Culture
Candida albicans - immunology
Child
Child, Preschool
Female
Humans
Immunotherapy
Immunotherapy - adverse effects
Immunotherapy - methods
Injections, Intralesional
Interferon
Interferon-gamma - blood
Lesions
Male
Medical personnel
Middle Aged
Patients
Physicians
Predictions
Predictive Value of Tests
Therapy
Warts
Warts - therapy
Young Adult
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Summary:Background Treatment of common warts remains a continuing challenge for both patients and physicians. Recently, intralesional immunotherapy by different antigens has proved efficacious in the treatment of warts, however, no definite predictive factors for successful therapy have been established. Herein, we evaluate the efficacy and safety of Candida antigen in the treatment of common warts and the significance of interferon gamma (IFN‐γ) in the prediction of successful therapy. Methods The study included 54 patients with multiple common warts. A blood sample was collected from patients before therapy, cultured, and treated with Candida antigen for evaluation of IFN‐γ. Candida antigen was directly injected into the largest wart at 2‐week intervals until complete clearance or for a maximum of five treatments. Follow‐up was made for 6 months to detect any recurrence. Results Complete clearance of the lesions was seen in 61.1% of the studied patients. IFN‐γ was statistically higher in responded cases as compared to nonresponders. Adverse effects were insignificant, and no recurrence of warts was observed. Conclusions Candida antigen is a promising, effective, and safe immunotherapeutic modality for common warts, and IFN‐γ may serve as a good predictor of its therapeutic response.
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.13709