Prevalence of transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults: systematic review and meta‐analysis

Objective To perform a systematic review and meta‐analysis on the prevalence of transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults. Methods We systematically reviewed and performed a meta‐analysis on the prevalence of TDP‐43 proteinopathy in older a...

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Bibliographic Details
Published in:Neuropathology and applied neurobiology 2018-04, Vol.44 (3), p.286-297
Main Authors: Nascimento, C., Di Lorenzo Alho, A. T., Bazan Conceição Amaral, C., Leite, R. E. P., Nitrini, R., Jacob‐Filho, W., Pasqualucci, C. A., Hokkanen, S. R. K., Hunter, S., Keage, H., Kovacs, G. G., Grinberg, L. T., Suemoto, C. K.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Brain
Brain - metabolism
Brain - pathology
brain ageing
Cognition
Cognition - physiology
dementia
Dementia disorders
Deoxyribonucleic acid
DNA
DNA-Binding Proteins - metabolism
elderly
Genetic factors
Hippocampus
Humans
Meta-analysis
Neurodegenerative diseases
Older people
Population genetics
post mortem
Prevalence
Reviews
Sclerosis
Standardization
Systematic review
TDP-43 Proteinopathies - diagnosis
TDP-43 Proteinopathies - epidemiology
TDP-43 Proteinopathies - metabolism
TDP-43 Proteinopathies - pathology
TDP‐43 proteinopathy
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Summary:Objective To perform a systematic review and meta‐analysis on the prevalence of transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults. Methods We systematically reviewed and performed a meta‐analysis on the prevalence of TDP‐43 proteinopathy in older adults with normal cognition, evaluated by the Mini‐Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP‐43 using random‐effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP‐43 aggregates, analysed brain regions, Braak stage, Consortium to Establish a Registry for Alzheimer's Disease score, hippocampal sclerosis and geographic location. Results A total of 505 articles were identified in the systematic review, and 7 were included in the meta‐analysis with 1196 cognitively normal older adults. We found an overall prevalence of TDP‐43 proteinopathy of 24%. Prevalence of TDP‐43 proteinopathy varied widely across geographic location (North America: 37%, Asia: 29%, Europe: 14%, and Latin America: 11%). Estimated prevalence of TDP‐43 proteinopathy also varied according to study quality (quality score >7: 22% vs. quality score
ISSN:0305-1846
1365-2990
1365-2990
DOI:10.1111/nan.12430