Hydrogen breath test to detect small intestinal bacterial overgrowth: a prevalence case–control study in autism

The aim of this study is to assess the prevalence of small intestinal bacterial overgrowth (SIBO) by hydrogen breath test in patients with autism spectrum disorders (ASD) with respect to a consistent control group. From 2011 to 2013, 310 children with ASD and 1240 sex- and age-matched typical childr...

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Bibliographic Details
Published in:European child & adolescent psychiatry 2018-02, Vol.27 (2), p.233-240
Main Authors: Wang, Li, Yu, Yu-Mei, Zhang, You-qi, Zhang, Jie, Lu, Na, Liu, Na
Format: Article
Language:English
Subjects:
Autism
Autistic children
Bacteria
Breath tests
Child & adolescent psychiatry
Child and Adolescent Psychiatry
Children
Fasting
Glucose
Hydrogen
Intestine
Medicine
Medicine & Public Health
Original Contribution
Psychiatry
Severity
Statistical analysis
Vaccines
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Summary:The aim of this study is to assess the prevalence of small intestinal bacterial overgrowth (SIBO) by hydrogen breath test in patients with autism spectrum disorders (ASD) with respect to a consistent control group. From 2011 to 2013, 310 children with ASD and 1240 sex- and age-matched typical children were enrolled in this study to undergo glucose breath test. The study participants were considered to exhibit SIBO when an increase in H 2 of ≥20 ppm or CH 4 of ≥10 ppm with respect to the fasting value was observed up to 60 min after the ingestion of glucose. Ninety-six children with autism suffered from SIBO, giving a prevalence rate of SIBO was 31.0% (95% CI 25.8–36.1%). In contrast, 9.3% of the typical children acknowledged SIBO. The difference between groups was statistically significant ( P  
ISSN:1018-8827
1435-165X
DOI:10.1007/s00787-017-1039-2