Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis

Background Breast cancer remains the number 1 lethal malignancy in women. With rising incidence and decreased mortality, the number of breast cancer survivors has increased. Consequently, sequelae, such as pain, are becoming more important. Purpose The purpose of this study was to identify risk fact...

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Bibliographic Details
Published in:Supportive care in cancer 2017-12, Vol.25 (12), p.3607-3643
Main Authors: Leysen, Laurence, Beckwée, David, Nijs, Jo, Pas, Roselien, Bilterys, Thomas, Vermeir, Sofie, Adriaenssens, Nele
Format: Article
Language:English
Subjects:
Aged
Biopsy
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast surgery
Cancer research
Cancer survivors
Cancer Survivors - psychology
Chemotherapy
Chronic pain
Endocrine therapy
Evidence-based medicine
Female
Health aspects
Health risk assessment
Humans
Incidence
Lymphatic system
Lymphedema
Mastectomy - adverse effects
Medicine
Medicine & Public Health
Meta-analysis
Middle Aged
Mortality
Nursing
Nursing Research
Oncology
Pain
Pain - etiology
Pain Medicine
Radiation therapy
Rehabilitation Medicine
Review Article
Risk Factors
Systematic review
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Summary:Background Breast cancer remains the number 1 lethal malignancy in women. With rising incidence and decreased mortality, the number of breast cancer survivors has increased. Consequently, sequelae, such as pain, are becoming more important. Purpose The purpose of this study was to identify risk factors for the development of pain in breast cancer survivors. Methods PubMed and Web of Science were systematically screened for studies encompassing risk factors for the development of pain in breast cancer survivors. Meta-analyses were carried out for risk factors described in more than one article. Moderator analysis was performed in case of high heterogeneity ( I 2  > 50%) across studies. Results Seventeen studies were found eligible. Meta-analyses were performed for 17 factors. Significant differences for the odds of developing chronic pain were found for BMI (overall OR: 1.34, 95%CI 1.08–1.67, p  = 0.008), education (overall OR: 1.23, 95%CI 1.07–1.42, p  = 0.005), lymphedema (overall OR: 2.58, 95%CI 1.93–3.46, p  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-017-3824-3