Prostate cancer detection among readers with different degree of experience using ultra-high b-value diffusion-weighted Imaging: Is a non-contrast protocol sufficient to detect significant cancer?

Aim To evaluate the accuracy of a T2-weighted (T2w) – and a parallel transmit zoomed b = 2000 s/mm2 (b2000) – diffusion-weighted imaging sequence among three readers with different degrees of experience for prostate cancer (Pca) detection. Methods Ninety-three patients with suspected Pca were enroll...

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Bibliographic Details
Published in:European radiology 2018-02, Vol.28 (2), p.869-876
Main Authors: Hausmann, D., Aksöz, N., von Hardenberg, J., Martini, T., Westhoff, N., Buettner, S., Schoenberg, S.O., Riffel, P.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biopsy
Cancer
Clinical Competence
Diagnostic Radiology
Diagnostic systems
Diffusion Magnetic Resonance Imaging - methods
Field of view
Histopathology
Humans
Imaging
Internal Medicine
Interventional Radiology
Lesions
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neuroradiology
Oncology
Patients
Prostate cancer
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Radiology
Readers
Sensitivity and Specificity
Ultrasound
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Summary:Aim To evaluate the accuracy of a T2-weighted (T2w) – and a parallel transmit zoomed b = 2000 s/mm2 (b2000) – diffusion-weighted imaging sequence among three readers with different degrees of experience for prostate cancer (Pca) detection. Methods Ninety-three patients with suspected Pca were enrolled. For b2000 a two-dimensional spatially-selective RF pulse using an echo-planar transmit trajectory was applied, and the field of view (FOV) was reduced to one-third. All three readers (Reader A: 7, B 4 and C 7a) were 100/100/94% for Readers A/B/C, respectively. Inter-reader agreement was generally good (Kappa A/B: 0.8; A/C: 0.82; B/C: 0.74). Conclusion B2000 in combination with a T2w could be useful to detect clinically significant Pca. Key Points • Significant prostate cancer using zoomed ultra-high b-value DWI was detected. • Diagnostic performance among readers with different degrees of experience was good. • mp- MRI of the prostate using a comprehensive non-contrast protocol is clinically feasible.
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-017-5004-8