Prostate cancer detection among readers with different degree of experience using ultra-high b-value diffusion-weighted Imaging: Is a non-contrast protocol sufficient to detect significant cancer?

Aim To evaluate the accuracy of a T2-weighted (T2w) – and a parallel transmit zoomed b = 2000 s/mm2 (b2000) – diffusion-weighted imaging sequence among three readers with different degrees of experience for prostate cancer (Pca) detection. Methods Ninety-three patients with suspected Pca were enroll...

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Published in:European radiology 2018-02, Vol.28 (2), p.869-876
Main Authors: Hausmann, D., Aksöz, N., von Hardenberg, J., Martini, T., Westhoff, N., Buettner, S., Schoenberg, S.O., Riffel, P.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biopsy
Cancer
Clinical Competence
Diagnostic Radiology
Diagnostic systems
Diffusion Magnetic Resonance Imaging - methods
Field of view
Histopathology
Humans
Imaging
Internal Medicine
Interventional Radiology
Lesions
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neuroradiology
Oncology
Patients
Prostate cancer
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Radiology
Readers
Sensitivity and Specificity
Ultrasound
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description Aim To evaluate the accuracy of a T2-weighted (T2w) – and a parallel transmit zoomed b = 2000 s/mm2 (b2000) – diffusion-weighted imaging sequence among three readers with different degrees of experience for prostate cancer (Pca) detection. Methods Ninety-three patients with suspected Pca were enrolled. For b2000 a two-dimensional spatially-selective RF pulse using an echo-planar transmit trajectory was applied, and the field of view (FOV) was reduced to one-third. All three readers (Reader A: 7, B 4 and C 7a) were 100/100/94% for Readers A/B/C, respectively. Inter-reader agreement was generally good (Kappa A/B: 0.8; A/C: 0.82; B/C: 0.74). Conclusion B2000 in combination with a T2w could be useful to detect clinically significant Pca. Key Points • Significant prostate cancer using zoomed ultra-high b-value DWI was detected. • Diagnostic performance among readers with different degrees of experience was good. • mp- MRI of the prostate using a comprehensive non-contrast protocol is clinically feasible.
doi_str_mv 10.1007/s00330-017-5004-8
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Methods Ninety-three patients with suspected Pca were enrolled. For b2000 a two-dimensional spatially-selective RF pulse using an echo-planar transmit trajectory was applied, and the field of view (FOV) was reduced to one-third. All three readers (Reader A: 7, B 4 and C &lt;1 years of experience in prostate MRI) independently evaluated b2000 with regard to the presence of suspicious lesions that displayed increased signal. The results were compared to histopathology obtained by real-time MR/ultrasound fusion and systematic biopsy. Results In 62 patients Pca was confirmed. One significant Pca (Gleason score (GS) 7b) was missed by Reader C. Overall, sensitivity/specificity/positive predictive value/negative predictive value were 90/71/86/79% for Reader A, 87/84/92/76% for Reader B and 85/74/87/72% for Reader C, respectively. Detection rates for significant Pca (GS &gt;7a) were 100/100/94% for Readers A/B/C, respectively. Inter-reader agreement was generally good (Kappa A/B: 0.8; A/C: 0.82; B/C: 0.74). Conclusion B2000 in combination with a T2w could be useful to detect clinically significant Pca. Key Points • Significant prostate cancer using zoomed ultra-high b-value DWI was detected. • Diagnostic performance among readers with different degrees of experience was good. • mp- MRI of the prostate using a comprehensive non-contrast protocol is clinically feasible.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-017-5004-8</identifier><identifier>PMID: 28799090</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Biopsy ; Cancer ; Clinical Competence ; Diagnostic Radiology ; Diagnostic systems ; Diffusion Magnetic Resonance Imaging - methods ; Field of view ; Histopathology ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Lesions ; Magnetic resonance imaging ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Neoplasm Grading ; Neuroradiology ; Oncology ; Patients ; Prostate cancer ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - pathology ; Radiology ; Readers ; Sensitivity and Specificity ; Ultrasound</subject><ispartof>European radiology, 2018-02, Vol.28 (2), p.869-876</ispartof><rights>European Society of Radiology 2017</rights><rights>European Radiology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2aca824743e7f0109b3f8de836442a3ed945189dbab0617624059eeca9d1851e3</citedby><cites>FETCH-LOGICAL-c372t-2aca824743e7f0109b3f8de836442a3ed945189dbab0617624059eeca9d1851e3</cites><orcidid>0000-0002-3816-3302</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28799090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hausmann, D.</creatorcontrib><creatorcontrib>Aksöz, N.</creatorcontrib><creatorcontrib>von Hardenberg, J.</creatorcontrib><creatorcontrib>Martini, T.</creatorcontrib><creatorcontrib>Westhoff, N.</creatorcontrib><creatorcontrib>Buettner, S.</creatorcontrib><creatorcontrib>Schoenberg, S.O.</creatorcontrib><creatorcontrib>Riffel, P.</creatorcontrib><title>Prostate cancer detection among readers with different degree of experience using ultra-high b-value diffusion-weighted Imaging: Is a non-contrast protocol sufficient to detect significant cancer?</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Aim To evaluate the accuracy of a T2-weighted (T2w) – and a parallel transmit zoomed b = 2000 s/mm2 (b2000) – diffusion-weighted imaging sequence among three readers with different degrees of experience for prostate cancer (Pca) detection. Methods Ninety-three patients with suspected Pca were enrolled. For b2000 a two-dimensional spatially-selective RF pulse using an echo-planar transmit trajectory was applied, and the field of view (FOV) was reduced to one-third. All three readers (Reader A: 7, B 4 and C &lt;1 years of experience in prostate MRI) independently evaluated b2000 with regard to the presence of suspicious lesions that displayed increased signal. The results were compared to histopathology obtained by real-time MR/ultrasound fusion and systematic biopsy. Results In 62 patients Pca was confirmed. One significant Pca (Gleason score (GS) 7b) was missed by Reader C. Overall, sensitivity/specificity/positive predictive value/negative predictive value were 90/71/86/79% for Reader A, 87/84/92/76% for Reader B and 85/74/87/72% for Reader C, respectively. Detection rates for significant Pca (GS &gt;7a) were 100/100/94% for Readers A/B/C, respectively. Inter-reader agreement was generally good (Kappa A/B: 0.8; A/C: 0.82; B/C: 0.74). Conclusion B2000 in combination with a T2w could be useful to detect clinically significant Pca. 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Methods Ninety-three patients with suspected Pca were enrolled. For b2000 a two-dimensional spatially-selective RF pulse using an echo-planar transmit trajectory was applied, and the field of view (FOV) was reduced to one-third. All three readers (Reader A: 7, B 4 and C &lt;1 years of experience in prostate MRI) independently evaluated b2000 with regard to the presence of suspicious lesions that displayed increased signal. The results were compared to histopathology obtained by real-time MR/ultrasound fusion and systematic biopsy. Results In 62 patients Pca was confirmed. One significant Pca (Gleason score (GS) 7b) was missed by Reader C. Overall, sensitivity/specificity/positive predictive value/negative predictive value were 90/71/86/79% for Reader A, 87/84/92/76% for Reader B and 85/74/87/72% for Reader C, respectively. Detection rates for significant Pca (GS &gt;7a) were 100/100/94% for Readers A/B/C, respectively. Inter-reader agreement was generally good (Kappa A/B: 0.8; A/C: 0.82; B/C: 0.74). Conclusion B2000 in combination with a T2w could be useful to detect clinically significant Pca. Key Points • Significant prostate cancer using zoomed ultra-high b-value DWI was detected. • Diagnostic performance among readers with different degrees of experience was good. • mp- MRI of the prostate using a comprehensive non-contrast protocol is clinically feasible.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28799090</pmid><doi>10.1007/s00330-017-5004-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3816-3302</orcidid></addata></record>
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subjects Aged
Aged, 80 and over
Biopsy
Cancer
Clinical Competence
Diagnostic Radiology
Diagnostic systems
Diffusion Magnetic Resonance Imaging - methods
Field of view
Histopathology
Humans
Imaging
Internal Medicine
Interventional Radiology
Lesions
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neuroradiology
Oncology
Patients
Prostate cancer
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Radiology
Readers
Sensitivity and Specificity
Ultrasound
title Prostate cancer detection among readers with different degree of experience using ultra-high b-value diffusion-weighted Imaging: Is a non-contrast protocol sufficient to detect significant cancer?
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