The Significance of Upfront Knowledge of N2 Disease in Non-small Cell Lung Cancer

Background Previous literature suggests that patients with non-small cell lung cancer (NSCLC) and unsuspected N2 disease (cN0, pN2) represent a distinct subgroup associated with improved overall survival compared to patients with N2 disease identified prior to resection (cN2, pN2). Methods Retrospec...

Full description

Saved in:
Bibliographic Details
Published in:World journal of surgery 2018, Vol.42 (1), p.161-171
Main Authors: Thomas, Daniel C., Arnold, Brian N., Rosen, Joshua E., Salazar, Michelle C., Detterbeck, Frank C., Blasberg, Justin D., Boffa, Daniel J., Kim, Anthony W.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Cancer
Cancer therapies
Cardiac Surgery
Chemotherapy
General Surgery
Lung cancer
Lung diseases
Medicine
Medicine & Public Health
Mortality
Multivariate analysis
Non-small cell lung carcinoma
Original Scientific Report
Patients
Radiation
Radiation therapy
Risk analysis
Risk factors
Surgery
Survival
Thoracic Surgery
Tumors
Vascular Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Previous literature suggests that patients with non-small cell lung cancer (NSCLC) and unsuspected N2 disease (cN0, pN2) represent a distinct subgroup associated with improved overall survival compared to patients with N2 disease identified prior to resection (cN2, pN2). Methods Retrospective analysis of the National Cancer Database of patients from 2004 to 2011 with cN0 and cN2 status found to be pathologic stage III-N2 NSCLC after surgical resection. Comparison of 5-year survival of patients with unsuspected N2 disease versus those with known N2 disease after surgical resection using Kaplan–Meier analysis was made. The independent effect of unsuspected N2 disease on mortality was analyzed using multivariate analysis. Results A total of 3271 patients with pathologic stage III-N2 NSCLC underwent curative intent surgical resection with or without adjuvant chemotherapy or chemotherapy and radiation. Unsuspected N2 disease was identified in 48% of patients. Patients with unsuspected N2 disease were more likely to have T1 tumors (37 vs. 32%, p  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-017-4165-6