Importance of a 5- versus 7-day pill-free interval in a GnRH antagonist protocol using corifollitropin alfa: a prospective cohort study in oocyte donors

In this prospective cohort study, oocyte donors were recruited prospectively and assigned to receive corifollitropin alfa: 5 days after pill discontinuation (group D5; 42 donors), or 7 days after pill discontinuation (group D7; 50 donors) in a gonadotrophin-releasing hormone antagonist protocol. Fix...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive biomedicine online 2017-10, Vol.35 (4), p.425-431
Main Authors: Pérez-Calvo, Alicia, Martínez, Francisca, Blockeel, Christophe, Clúa, Elisabeth, Rodríguez, Ignacio, Barri, Pere N., Coroleu, Buenaventura
Format: Article
Language:English
Subjects:
Adult
Contraceptives, Oral - administration & dosage
Corifollitropin alfa
Drug Administration Schedule
Female
Follicle Stimulating Hormone, Human - administration & dosage
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Humans
Living Donors
Oocyte donors
Oocytes - transplantation
Ovarian stimulation
Pill-free interval
Prospective Studies
Tissue Donors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this prospective cohort study, oocyte donors were recruited prospectively and assigned to receive corifollitropin alfa: 5 days after pill discontinuation (group D5; 42 donors), or 7 days after pill discontinuation (group D7; 50 donors) in a gonadotrophin-releasing hormone antagonist protocol. Fixed additional daily doses of 200 IU recombinent FSH (rFSH) were started after 7 days of corifollitropinalfa, until triggering. No significant differences in basal characteristics were observed between both groups. In group D5, mean (SD) total additional rFSH dose was 659 (452) IU; in group D7, total rFSH dose was 459 (356) IU (P = 0.022). Duration of stimulation was significantly longer in group D5 compared with group D7 (P = 0.002). No differences were found in total number of oocytes obtained. Total number of injections was significantly lower in group D7 compared with group D5 (9.8 [3.2] versus 11.9 [3.9], respectively; P = 0.004). Total cost of medication used for donor treatment was significantly higher in group D5 than in group D7 (P = 0.015). After more than 22 days of pill-taking, extending the pill-free interval to 7 days significantly reduces the total dose of gonadotrophins, duration of stimulation, total cost of medication and total number of injections.
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2017.06.025