Different nerve ultrasound patterns in charcot‐marie‐tooth types and hereditary neuropathy with liability to pressure palsies

ABSTRACT Introduction Nerve ultrasound in Charcot–Marie–Tooth (CMT) disease has focused mostly on the upper limbs. We performed an evaluation of a large cohort of CMT patients in which we sonographically characterized nerve abnormalities in different disease types, ages, and nerves. Methods Seventy...

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Bibliographic Details
Published in:Muscle & nerve 2018-01, Vol.57 (1), p.E18-E23
Main Authors: Padua, Luca, Coraci, Daniele, Lucchetta, Marta, Paolasso, Ilaria, Pazzaglia, Costanza, Granata, Giuseppe, Cacciavillani, Mario, Luigetti, Marco, Manganelli, Fiore, Pisciotta, Chiara, Piscosquito, Giuseppe, Pareyson, Davide, Briani, Chiara
Format: Article
Language:English
Subjects:
Abnormalities
Charcot-Marie-Tooth disease
Demyelination
Enlargement
Entrapment
Evaluation
Liability
Limbs
Muscles
nerve
Nerves
Neuropathy
Patients
Pressure
rehabilitation
Symmetry
Ultrasonic imaging
Ultrasound
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Summary:ABSTRACT Introduction Nerve ultrasound in Charcot–Marie–Tooth (CMT) disease has focused mostly on the upper limbs. We performed an evaluation of a large cohort of CMT patients in which we sonographically characterized nerve abnormalities in different disease types, ages, and nerves. Methods Seventy patients affected by different CMT types and hereditary neuropathy with liability to pressure palsies (HNPP) were evaluated, assessing median, ulnar, fibular, tibial, and sural nerves bilaterally. Data were correlated with age. Results Nerve dimensions were correlated with CMT type, age, and nerve site. Nerves were larger in demyelinating than in axonal neuropathies. Nerve involvement was symmetric. Discussion CMT1 patients had larger nerves than did patients with other CMT types. Patients with HNPP showed enlargement at entrapment sites. Our study confirms the general symmetry of ultrasound nerve patterns in CMT. When compared with ultrasound studies of nerves of the upper limbs, evaluation of the lower limbs did not provide additional information. Muscle Nerve 57: E18–E23, 2018
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25766