QRS duration reflects underlying changes in conduction velocity during increased intraventricular pressure and heart failure

Pressure overload and heart failure electrophysiological remodeling (HF-ER) in pigs are associated with decreased conduction velocity (CV) and dispersion of repolarization, which lead to higher risk of ventricular arrhythmia. This work aimed to establish the correlation between QRS complex duration...

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Published in:Progress in biophysics and molecular biology 2017-11, Vol.130 (Pt B), p.394-403
Main Authors: Quintanilla, Jorge G., Moreno, Javier, Archondo, Tamara, Alfonso-Almazán, José Manuel, Lillo-Castellano, José María, Usandizaga, Elena, García-Torrent, María Jesús, Rodríguez-Bobada, Cruz, González, Pablo, Borrego, Luis, Cañadas-Godoy, Victoria, González-Ferrer, Juan J., Pérez-Castellano, Nicasio, Pérez-Villacastín, Julián, Filgueiras-Rama, David
Format: Article
Language:English
Subjects:
Afterload
Animals
Electrocardiography
Heart Conduction System - physiopathology
Heart failure
Heart Failure - physiopathology
Intraventricular pressure
Optical mapping
Remodeling
Swine
Ventricular Pressure
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Summary:Pressure overload and heart failure electrophysiological remodeling (HF-ER) in pigs are associated with decreased conduction velocity (CV) and dispersion of repolarization, which lead to higher risk of ventricular arrhythmia. This work aimed to establish the correlation between QRS complex duration and underlying changes in CV during increased intraventricular pressure (IVP) and/or HF-ER ex-vivo, and to determine whether QRS duration could be sensitive to an acute increase in left ventricular (LV) afterload in-vivo. HF-ER was induced in 7 pigs by high-rate ventricular pacing. Seven weight-matched animals were used as controls. Isolated Langendorff-perfused hearts underwent programmed ventricular stimulation to study QRS complex duration and CV under low/high IVP, using volume-conducted ECG and epicardial optical mapping, respectively. Four additional pigs underwent open-chest surgery to increase LV afterload by partially clamping the ascending aorta, while measuring QRS complex duration during sinus rhythm (SR). In 13 hearts included for analysis, both HF-ER and increased IVP showed significantly slower epicardial CV (−40% and −15%, p 
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2017.08.003