T-Cell Receptor Signaling Events Triggering Granule Exocytosis

T-cell receptor (TCR) engagement by antigen results in proliferation, differentiation and cytokine secretion. In the CD8 super(+) T-cell subset, TCR triggering also induces granule exocytosis, the directional release of contents of lysosome-like granules toward the target cell presenting the antigen...

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Bibliographic Details
Published in:Critical Reviews in Immunology 2006-01, Vol.26 (3), p.265-290
Main Authors: Radoja, S, Frey, AB, Vukmanovic, S
Format: Article
Language:English
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Summary:T-cell receptor (TCR) engagement by antigen results in proliferation, differentiation and cytokine secretion. In the CD8 super(+) T-cell subset, TCR triggering also induces granule exocytosis, the directional release of contents of lysosome-like granules toward the target cell presenting the antigen. This process is responsible for immediate death of target cells. The intracellular events required for granule exocytosis are distinct from those of proliferation and cytokine secretion, as the former do not require de novo protein synthesis. Consequently, the key TCR signaling events required for granule exocytosis may be distinct. In this article, we review present knowledge of regulation of granule exocytosis by molecules of the TCR signaling cascade.
ISSN:1040-8401
1365-2567
DOI:10.1615/critrevimmunol.v26.i3.40