Using factorial experiments to study the toxicity of metal mixtures

Two-level factorial experiments were employed in this study for understanding and predicting the toxicity of binary and ternary metal mixtures. Toxicity of metal mixtures with concentrations between the respective EC 10 and EC 80 values was experimentally measured. Models were fit to the experimenta...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2004-09, Vol.59 (1), p.38-43
Main Authors: Ren, Shijin, Mee, Robert W, Frymier, Paul D
Format: Article
Language:English
Subjects:
Animal, plant and microbial ecology
Applied ecology
Bacterial Proteins - analysis
Biological and medical sciences
Cadmium - toxicity
Copper - toxicity
Ecotoxicology, biological effects of pollution
Environmental Monitoring
Factor Analysis, Statistical
Factorial experiments
Forecasting
Fundamental and applied biological sciences. Psychology
General aspects
Lead - toxicity
Luminescent Measurements
Metal
Mixture
Models, Theoretical
Shk1
Toxicity
Water Pollutants, Chemical - toxicity
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Summary:Two-level factorial experiments were employed in this study for understanding and predicting the toxicity of binary and ternary metal mixtures. Toxicity of metal mixtures with concentrations between the respective EC 10 and EC 80 values was experimentally measured. Models were fit to the experimental data and the resultant models were of high quality as reflected by R 2 (coefficient of determination). Interactions between mixture components were indicated by the existence of statistically significant interaction terms in the models. Toxicity predictions based on the models were compared with observed toxicity for binary and ternary metal mixtures. The models developed did not assume additivity between metals, were simple and interpretable, and gave satisfactory predictions of the toxicity of metal mixtures in aqueous solutions without requiring knowledge on synergism or antagonism.
ISSN:0147-6513
1090-2414
DOI:10.1016/S0147-6513(03)00099-X