Cerebral venous sinus Thrombosis: Clinical Features, Long-Term outcome and recanalization

• Published in: Journal of clinical neuroscience 2017-11, Vol.45, p.248-251
• Main Authors: Gazioglu, Sibel, Eyuboglu, Ilker, Yildirim, Ahmet, Aydin, Cigdem Ozen, Alioglu, Zekeriya
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Anticoagulants - therapeutic use; Cerebral venous sinus thrombosis; Clinical outcome; Endovascular Procedures - methods; Female; Humans; Male; Middle Aged; Prognosis; Recanalization; Retrospective Studies; Sinus Thrombosis, Intracranial - diagnosis; Sinus Thrombosis, Intracranial - therapy; Treatment Outcome; Young Adult
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2017.07.028

•The recanalization rate and prognosis of cerebral venous sinus thrombosis are good.•Patients with extensive thrombosis have lower complete recanalization rates.•There is no significant association between recanalization status and outcome. Recanalization and prognosis of cerebral venous sinus thrombosis (CVST) are generally considered to be good, and various factors have been reported to be associated with recanalization in previous studies. Fifty patients diagnosed with CVST between September 2007 and July 2016 were analyzed retrospectively. Modified Rankin scale (mRS) scores at six months and results of follow-up imaging of patients with at least six months follow-up were also reviewed for the assessment of long term outcome, recanalization rates and factors associated with recanalization. The mean age of the patients (39 female, 11 male) was 34.6±11.2years (17–69). Of the 50 patients enrolled, 31 (62%) had at least six months follow-up with available data and 26 (83.9%) of these had favorable outcomes (mRS 0–1) at six months. Complete recanalization was observed in 15 patients (48.4%), partial recanalization in 14 (45.2%) and no recanalization in 2 (6.5%). Univariate analysis revealed that complete recanalization rates were higher in female patients (p=0.013) and lower in patients with multiple thrombosis in more than one dural sinus (p=0.03). The prognosis and recanalization rates of CVST were good, and complete or partial recanalization of venous sinuses was not associated with clinical outcome.