A role of the endothelial nitric oxide system in acute renal colic caused by ureteral stone

• Published in: The American journal of emergency medicine 2018-02, Vol.36 (2), p.266-270
• Main Authors: Bulbul, Emre, Sener, Elif Funda, Gunay, Nahide Ekici, Taslidere, Bahadir, Taslidere, Elif, Koyuncu, Serhat, Gunay, Nurullah
• Format: Article
• Language: English
• Subjects: Adult; Blood & organ donations; Cardiovascular disease; Data processing; Emergency department; Emergency medical care; Emergency medical services; Emergency services; Endothelial nitric oxide system; Enzymes; Family medical history; Female; Gene expression; Gene polymorphism; Genomes; Genotype; Genotypes; Humans; Hypertension; Kidney diseases; Kidneys; Laboratories; Male; Medical imaging; Medicine; Mutation; Nitric oxide; Nitric Oxide - genetics; Nitric Oxide Synthase Type III - genetics; Nitric-oxide synthase; Pain; Pain - etiology; Patients; Peripheral blood; Polymorphism, Genetic - genetics; Prospective Studies; Renal colic; Renal Colic - genetics; Rodents; Smooth muscle; Statistical analysis; Stem cells; Studies; Ultrasonic imaging; Ureteral Calculi - genetics; Urinary stone disease
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/j.ajem.2017.08.008

Endothelial nitric oxide synthase gene polymorphisms play a role in some pathophysiological processes. In this study, the possible effects of endothelial nitric oxide synthase gene polymorphisms on ureteral stone disease in patients who were admitted to the emergency department with severe pain due to renal colic are examined. The study groups were designed as controls and patients. The control group was formed from the healthy volunteers who applied to the blood center next to the emergency service. The patient group comprised patients who were diagnosed with ureteral stone disease with severe pain. All of the genetic studies were based on extracted peripheral blood samples using the necessary procedures from the Genome and Stem Cell Center at Erciyes University (GENKOK). The data were analyzed with SPSS (IBM, ver 20, United Sate). The study group comprised 62 females and 138 males, and the control group comprised 64 females and 136 males. All of the stones that caused renal colic were found to be localized in the ureters and the ureterovesical junction. The genotypes of the intron 4 polymorphism were found to be as follows: 4a/4a in 10 people, 4b/4a in 115, and 4b/4b in 275 people. The GG genotype of the eNOS-G894T polymorphism was found in 108 patients in the study group and in117 of the healthy individuals. There was no statistically significant difference between the two groups regarding these data. Although this study is the first in the literature to examine the relationship between renal colic and endothelial nitric oxide synthase gene polymorphisms, our study demonstrated that no relation was found.