HPV-11 variability, persistence and progression to genital warts in men: the HIM study

HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, prec...

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Published in:Journal of general virology 2017-09, Vol.98 (9), p.2339-2342
Main Authors: Flores-Díaz, Ema, Sereday, Karen A, Ferreira, Silvaneide, Sirak, Bradley, Sobrinho, João Simão, Baggio, Maria Luiza, Galan, Lenice, Silva, Roberto C, Lazcano-Ponce, Eduardo, Giuliano, Anna R, Villa, Luisa L, Sichero, Laura
Format: Article
Language:English
Subjects:
Adolescent
Adult
Condylomata Acuminata - pathology
Condylomata Acuminata - virology
Disease Progression
Genotype
Human papillomavirus 11 - classification
Human papillomavirus 11 - genetics
Human papillomavirus 11 - isolation & purification
Human papillomavirus 11 - physiology
Humans
Male
Phylogeny
Young Adult
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Summary:HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases. The same HPV-11 variant was detected in the GW sample and its preceding genital swab. There was a lack of association between any particular HPV-11 variant and the increased risk for GW development.
ISSN:0022-1317
1465-2099
DOI:10.1099/jgv.0.000896