Signaling networks in the control of pluripotency

Embryonic stem cells (ESCs) are characterized by their ability of unlimited self-renewal in vitro and pluripotent developmental potential, which endows them with great values in basic research and future clinical application. However, realization of full potential of ESCs is dependent on the elucida...

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Bibliographic Details
Published in:Current opinion in genetics & development 2017-10, Vol.46, p.141-148
Main Authors: Zhao, Hanzhi, Jin, Ying
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - genetics
Cell Self Renewal - genetics
Embryonic Stem Cells
Humans
Mice
Signal Transduction - genetics
Transcription Factors - genetics
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Summary:Embryonic stem cells (ESCs) are characterized by their ability of unlimited self-renewal in vitro and pluripotent developmental potential, which endows them with great values in basic research and future clinical application. However, realization of full potential of ESCs is dependent on the elucidation of molecular mechanisms governing ESCs, among which signaling pathways play critical roles. A great deal of efforts has been made in the past decades to understand what and how signaling pathways contribute to the establishment and maintenance of pluripotency. In this review, we discuss signaling networks in both mouse and human ESCs, focusing on signals involved in the control of self-renewal and differentiation. In addition, the modulation of signaling pathways by pluripotency-associated transcription factors is also briefly summarized.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2017.07.013