Application of transcutaneous ultrasonography for the diagnosis of muscle mass loss in patients with liver cirrhosis

Background To propose an ultrasound-based parameter for the diagnosis of muscle mass loss (MML) in cirrhosis. Methods This is an IRB-approved cross-sectional study (October 2013 to January 2017) with written informed consent including 357 subjects—234 cirrhosis and 123 controls. MML was diagnosed us...

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Bibliographic Details
Published in:Journal of gastroenterology 2018-05, Vol.53 (5), p.652-659
Main Authors: Kobayashi, Kazufumi, Maruyama, Hitoshi, Kiyono, Soichiro, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Chiba, Tetsuhiro, Kato, Naoya, Yamaguchi, Tadashi
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Area Under Curve
Biliary Tract
Body mass index
Care and treatment
Case-Control Studies
Cirrhosis
Colorectal Surgery
Computed tomography
Cross-Sectional Studies
CT imaging
Diagnosis
Diagnostic imaging
Female
Females
Gastroenterology
Hepatology
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Male
Males
Medical diagnosis
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Muscles
Muscular Atrophy - diagnostic imaging
Muscular Atrophy - etiology
Original Article—Liver
Pancreas
Psoas Muscles - diagnostic imaging
ROC Curve
Severity of Illness Index
Skeletal muscle
Surgical Oncology
Tomography, X-Ray Computed
Ultrasonic imaging
Ultrasonography
Ultrasound
Ultrasound imaging
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Summary:Background To propose an ultrasound-based parameter for the diagnosis of muscle mass loss (MML) in cirrhosis. Methods This is an IRB-approved cross-sectional study (October 2013 to January 2017) with written informed consent including 357 subjects—234 cirrhosis and 123 controls. MML was diagnosed using the skeletal muscle index at the L3 level (L3-SMI) on computed tomography (CT). Transcutaneous ultrasound was used to demonstrate a cross section of the right iliopsoas muscle, and the iliopsoas muscle index (IP index) was defined by the iliopsoas muscle area/height 2 (mm 2 /m 2 ). Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic ability of IP index for MML. Results The iliopsoas muscle was detected in all subjects. The IP index was lower in cirrhosis than in controls: males (211.2 ± 73.8 vs. 295.5 ± 139.4, P  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-017-1378-2