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Discrepant HPV/cytology cotesting results: Are there differences between cytology‐negative versus HPV‐negative cervical intraepithelial neoplasia?

BACKGROUND The objective of this study was to compare cervical high‐grade squamous intraepithelial lesions subcategorized as cervical intraepithelial neoplasia‐3 (CIN‐3)–positive after a negative cytology result but positive for high‐risk human papillomavirus (HR‐HPV) testing to those with a negativ...

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Bibliographic Details
Published in:Cancer cytopathology 2017-10, Vol.125 (10), p.795-805
Main Authors: Tracht, Jessica M., Davis, Antoinette D., Fasciano, Danielle N., Eltoum, Isam‐Eldin A.
Format: Article
Language:English
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Summary:BACKGROUND The objective of this study was to compare cervical high‐grade squamous intraepithelial lesions subcategorized as cervical intraepithelial neoplasia‐3 (CIN‐3)–positive after a negative cytology result but positive for high‐risk human papillomavirus (HR‐HPV) testing to those with a negative HR‐HPV test but positive cytology (atypical squamous cells of undetermined significance [ASCUS]‐positive/HPV‐negative) and to assess reasons for discrepancies. METHODS The authors retrospectively analyzed women who underwent screening with cytology and HPV testing from 2010 through 2013. After a review of surgical specimens and cytology, discrepancies were classified as sampling or interpretation error. Clinical and pathologic findings were compared. RESULTS In total, 15,173 women (age range, 25‐95 years; 7.1% were aged 
ISSN:1934-662X
1934-6638
DOI:10.1002/cncy.21905