Sub-chronic exposure to low concentration of dibutyl phthalate affects anthropometric parameters and markers of obesity in rats

Dibutyl phthalate is an important phthalate ester extensively used in various products like plastics, adhesives, inks, pharmaceuticals, lacquers, varnishes, paper coatings, safety glasses, and cosmetics. The exposure of DBP to “one’s health” is therefore inevitable. The present study focuses on eluc...

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Bibliographic Details
Published in:Environmental science and pollution research international 2017-11, Vol.24 (32), p.25462-25467
Main Authors: Majeed, Khalid Abdul, ur Rehman, Habib, Yousaf, Muhammad Shahbaz, Zaneb, Hafsa, Rabbani, Imtiaz, Tahir, Sajid Khan, Rashid, Muhammad Afzal
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Animal Nutritional Physiological Phenomena - drug effects
Animals
Anthropometry
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Biomarkers - metabolism
Body mass index
Body measurements
Body size
Body weight
Body weight gain
Body Weights and Measures
Cholesterol
Chronic exposure
Cosmetics
Creatinine
Data processing
Dibutyl phthalate
Dibutyl Phthalate - adverse effects
Earth and Environmental Science
Ecotoxicology
Endocrine disruptors
Environment
Environmental Chemistry
Environmental Health
Environmental Pollutants - adverse effects
Environmental science
Feed conversion
Feed efficiency
Female
Inks
Interaction parameters
L-Lactate dehydrogenase
Lacquers
Lactate dehydrogenase
Lactic acid
Male
Markers
Nutrition Assessment
Obesity
Obesity - chemically induced
Phthalates
Polymers
Product safety
Protective equipment
Rats
Research Article
Rodents
Serum albumin
Thorax
Transaminase
Variance analysis
Varnishes
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Dibutyl phthalate is an important phthalate ester extensively used in various products like plastics, adhesives, inks, pharmaceuticals, lacquers, varnishes, paper coatings, safety glasses, and cosmetics. The exposure of DBP to “one’s health” is therefore inevitable. The present study focuses on elucidating the effect of low doses of DBP on anthropometric parameters and markers of obesity in rats in a 13-week study. A total of 48 rats were divided into three treatment groups as mg DBP/kg body weight per day: (a) 0 mg/kg (control), (b) 10 mg/kg (DBP-10), and (c) 50 mg/kg (DBP-50). The rats in each treatment ( n  = 16) were further equally divided into male and female rats for studying treatment and gender interaction. Anthropometric parameters, nutritional determinants, and markers of obesity in rats were studied. Two-way ANOVA was used to analyze the data ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-017-9952-y