The long noncoding RNA SNHG1 promotes tumor growth through regulating transcription of both local and distal genes

Increasing evidence indicates that long noncoding RNAs (lncRNAs) have important roles in various physiological processes and dysfunction of lncRNAs could be a prevalent cause in human diseases. Here we functionally characterized the nuclear-enriched lncRNA SNHG1 , which is highly expressed in multip...

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Bibliographic Details
Published in:Oncogene 2017-12, Vol.36 (49), p.6774-6783
Main Authors: Sun, Y, Wei, G, Luo, H, Wu, W, Skogerbø, G, Luo, J, Chen, R
Format: Article
Language:English
Subjects:
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A549 Cells
AKT protein
Animals
Apoptosis
Cancer
Cancer cells
Carcinogenesis - genetics
Cell Biology
Cell Line, Tumor
Cell Proliferation - genetics
Development and progression
Gene expression
Gene Expression Regulation, Neoplastic
Growth
HCT116 Cells
Human Genetics
Humans
Internal Medicine
K562 Cells
Male
MCF-7 Cells
Medicine
Medicine & Public Health
Mice, Inbred BALB C
Mice, Nude
Myc protein
Non-coding RNA
Oncology
original-article
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Signal transduction
Transcription
Transplantation, Heterologous
Tumorigenesis
Tumors
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Summary:Increasing evidence indicates that long noncoding RNAs (lncRNAs) have important roles in various physiological processes and dysfunction of lncRNAs could be a prevalent cause in human diseases. Here we functionally characterized the nuclear-enriched lncRNA SNHG1 , which is highly expressed in multiple types of cancer. We also provide evidence that SNHG1 promotes cancer cell growth by regulating gene expression both in cis and in trans . SNHG1 was involved in the AKT signaling pathway as it promotes the neighboring transcription of the protein-coding gene SLC3A2 in cis by binding the Mediator complex to facilitate the establishment of enhancer–promoter interaction. In trans , SNHG1 directly interacted with central domain of FUBP1 and antagonize the binding of FBP-interacting repressor to FUBP1, thereby coordinating the expression of the oncogene MYC . Collectively, our findings demonstrate that lncRNA SNHG1 can function both in cis and in trans with distinct mechanisms to regulate transcription, promoting tumorigenesis and cancer progression.
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2017.286