Surgical debulking of pituitary adenomas improves responsiveness to octreotide lar in the treatment of acromegaly

Background Studies comparing primary medical treatment of acromegaly with surgery are often non-randomized, and not stratified by illness severity. We prospectively compared primary medical therapy with pituitary surgery in patients with acromegaly. All patients had macroadenomas, at least one rando...

Full description

Saved in:
Bibliographic Details
Published in:Pituitary 2017-12, Vol.20 (6), p.668-675
Main Authors: Fahlbusch, Rudolf, Kleinberg, David, Biller, Beverly, Bonert, Vivien, Buchfelder, Michael, Cappabianca, Paolo, Carmichael, John, Chandler, William, Colao, Annamaria, George, Ajax, Klibanski, Anne, Knopp, Edmond, Kreutzer, Juergen, Kundurti, Neehar, Lesser, Martin, Mamelak, Adam, Pivonello, Rosario, Post, Kalmon, Swearingen, Brooke, Vance, Mary Lee, Barkan, Ariel
Format: Article
Language:English
Subjects:
Acromegaly
Acromegaly - drug therapy
Acromegaly - metabolism
Adult
Aged
Antineoplastic Agents, Hormonal - therapeutic use
Endocrinology
Female
Glucose tolerance
Glucose Tolerance Test
Growth hormones
Human Growth Hormone - metabolism
Human Physiology
Humans
Insulin-like growth factor I
Male
Medicine
Medicine & Public Health
Middle Aged
Octreotide
Octreotide - therapeutic use
Pituitary
Pituitary Neoplasms - drug therapy
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - surgery
Prospective Studies
Surgery
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Studies comparing primary medical treatment of acromegaly with surgery are often non-randomized, and not stratified by illness severity. We prospectively compared primary medical therapy with pituitary surgery in patients with acromegaly. All patients had macroadenomas, at least one random human growth hormone (GH) level ≥12.5 ng/mL, elevated IGF-I levels and failure to suppress GH to
ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-017-0832-8