Nucleophilic trifluoromethylation of electron-deficient arenes

A novel trifluoromethylation of arenes is presented, which proceeds under mild reaction conditions and has the potential for late-stage functionalisation of pharmaceuticals and agrochemicals. The new reaction allows for the regioselective conversion of nitroarenes into 1,2-trifluoromethylated nitroa...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-08, Vol.53 (71), p.9858-9861
Main Authors: Pike, Jack A, Walton, James W
Format: Article
Language:English
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Summary:A novel trifluoromethylation of arenes is presented, which proceeds under mild reaction conditions and has the potential for late-stage functionalisation of pharmaceuticals and agrochemicals. The new reaction allows for the regioselective conversion of nitroarenes into 1,2-trifluoromethylated nitroarenes, via a C-H activation pathway. Furthermore, a substitution of nitroarenes to trifluoromethyl arenes is also presented.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc05415g