Incidence and survival trends for medulloblastomas in the United States from 2001 to 2013

Population-based data examining recent epidemiological trends in medulloblastoma, the most common pediatric brain malignancy, are limited. Therefore, we sought to examine recent population-level trends in medulloblastoma incidence and survival. Central Brain Tumor Registry of the United States (CBTR...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuro-oncology 2017-12, Vol.135 (3), p.433-441
Main Authors: Khanna, Vishesh, Achey, Rebecca L., Ostrom, Quinn T., Block-Beach, Hunter, Kruchko, Carol, Barnholtz-Sloan, Jill S., de Blank, Peter M.
Format: Article
Language:English
Subjects:
Adenomatous polyposis coli
Adolescent
Age Factors
Brain tumors
Cancer
Central Nervous System Neoplasms - epidemiology
Child
Child, Preschool
Data processing
Epidemiology
Female
Humans
Incidence
Infant
Kaplan-Meier Estimate
Laboratory Investigation
Male
Males
Medicine
Medicine & Public Health
Medulloblastoma
Medulloblastoma - epidemiology
Neurology
Oncology
Proportional Hazards Models
SEER Program
Sex Factors
Survival
Trends
United States - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Population-based data examining recent epidemiological trends in medulloblastoma, the most common pediatric brain malignancy, are limited. Therefore, we sought to examine recent population-level trends in medulloblastoma incidence and survival. Central Brain Tumor Registry of the United States (CBTRUS) data were analyzed from 2001 to 2013. Age-adjusted incidence rates (IR) and annual percent changes (APCs) with 95% confidence intervals (CI) were calculated by age, sex, and race. Relative survival rates were calculated by age, sex, and race using Surveillance, Epidemiology and End-Results (SEER) registries; subsets of CBTRUS data. Kaplan–Meier and Cox proportional hazards models were used to examine survival differences. Medulloblastoma incidence remained relatively stable from 2001 to 2013, with minor fluctuations from 2001 to 2009 (APC = 2.2, 95% CI 0.8, 3.5) and 2009–2013 (APC = −4.1, 95% CI −7.5, −0.6). Incidence was highest in patients aged 1–4 years at diagnosis, but patients aged 10–14 years showed increased incidence from 2000 to 2013 (APC = 3.2, 95% CI 0.6, 5.8). Males displayed higher IR relative to females (males: 0.16 vs. females: 0.12), except in patients 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-017-2594-6