Selective photothermal inactivation of cells labeled with near-infrared croconaine dye

Photothermal inactivation of cells caused by laser heating of a near-infrared croconaine dye is more effective when the dye is located inside the cell. The cell inactivation is spatially confined - laser irradiation of a mixed population of two different cell lines produces selective inactivation of...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-08, Vol.53 (71), p.9906-9909
Main Authors: Harmatys, Kara M, Battles, Paul M, Peck, Evan M, Spence, Graeme T, Roland, Felicia M, Smith, Bradley D
Format: Article
Language:English
Subjects:
Animals
Cell Survival - drug effects
CHO Cells
Cricetulus
Cyclobutanes - chemical synthesis
Cyclobutanes - chemistry
Cyclobutanes - pharmacology
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Infrared Rays
Lasers
Molecular Structure
Photochemical Processes
Temperature
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Summary:Photothermal inactivation of cells caused by laser heating of a near-infrared croconaine dye is more effective when the dye is located inside the cell. The cell inactivation is spatially confined - laser irradiation of a mixed population of two different cell lines produces selective inactivation of the cells labeled with croconaine dye and does not harm adjacent unlabeled cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc05196d