[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of...

Full description

Saved in:
Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2018-04, Vol.109, p.143-146
Main Authors: Eekhoff, E. Marelise W., Botman, Esmée, Coen Netelenbos, J., de Graaf, Pim, Bravenboer, Nathalie, Micha, Dimitra, Pals, Gerard, de Vries, Teun J., Schoenmaker, Ton, Hoebink, Max, Lammertsma, Adriaan A., Raijmakers, Pieter G.H.M.
Format: Article
Language:English
Subjects:
[18F]NaF PET/CT
Adult
Disease marker
Female
Fibrodysplasia ossificans progressiva (FOP)
Flare-up
Heterotopic ossification (HO)
Humans
Myositis Ossificans - diagnostic imaging
Ossification, Heterotopic - diagnostic imaging
Positron Emission Tomography Computed Tomography - methods
Sodium Fluoride - analysis
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery. This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP. •[18F]NaF PET/CT is the first marker of (early) HO formation in FOP.•HO may start 3 weeks after a new flare-up•[18F]NaF PET/CT can quantify the HO process
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2017.08.012