The combination of indocyanine green clearance test and model for end-stage liver disease score predicts early graft outcome after liver transplantation

Early allograft dysfunction (EAD) and early postoperative complications are two important clinical endpoints when evaluating clinical outcomes of liver transplantation (LT). We developed and validated two ICGR15-MELD models in 87 liver transplant recipients for predicting EAD and early postoperative...

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Bibliographic Details
Published in:Journal of clinical monitoring and computing 2018-06, Vol.32 (3), p.471-479
Main Authors: Yunhua, Tang, Weiqiang, Ju, Maogen, Chen, Sai, Yang, Zhiheng, Zhang, Dongping, Wang, Zhiyong, Guo, Xiaoshun, He
Format: Article
Language:English
Subjects:
Adult
Anesthesiology
Area Under Curve
Critical Care Medicine
End Stage Liver Disease - diagnosis
End Stage Liver Disease - physiopathology
Female
Graft Survival
Health Sciences
Humans
Incidence
Indocyanine Green - chemistry
Intensive
Liver
Liver Function Tests
Liver Transplantation
Liver transplants
Male
Mathematical models
Medicine
Medicine & Public Health
Middle Aged
Model testing
Original Research
Postoperative Complications
Predictive Value of Tests
Reproducibility of Results
Risk Factors
ROC Curve
Sensitivity
Sensitivity and Specificity
Severity of Illness Index
Statistics for Life Sciences
Transplantation
Transplants & implants
Treatment Outcome
Young Adult
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Summary:Early allograft dysfunction (EAD) and early postoperative complications are two important clinical endpoints when evaluating clinical outcomes of liver transplantation (LT). We developed and validated two ICGR15-MELD models in 87 liver transplant recipients for predicting EAD and early postoperative complications after LT by incorporating the quantitative liver function tests (ICGR15) into the MELD score. Eighty seven consecutive patients who underwent LT were collected and divided into a training cohort (n = 61) and an internal validation cohort (n = 26). For predicting EAD after LT, the area under curve (AUC) for ICGR15-MELD score was 0.876, with a sensitivity of 92.0% and a specificity of 75.0%, which is better than MELD score or ICGR15 alone. The recipients with a ICGR15-MELD score ≥0.243 have a higher incidence of EAD than those with a ICGR15-MELD score 
ISSN:1387-1307
1573-2614
DOI:10.1007/s10877-017-0051-x