Antibacterial and anti-encrustation biodegradable polymer coating for urinary catheter

[Display omitted] Bacterial biofilm and crystalline deposits are the common causes of failure of long-term indwelling urinary catheter. Bacteria colonise the catheter surface causing serious infections in the urinary tract and encrustations that can block the catheter and induce trauma in patients....

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Bibliographic Details
Published in:International journal of pharmaceutics 2017-10, Vol.531 (1), p.205-214
Main Authors: Dayyoub, Eyas, Frant, Marion, Pinnapireddy, Shashank Reddy, Liefeith, Klaus, Bakowsky, Udo
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Bacterial adhesion
Biofilms
Encrustation
Humans
Metal Nanoparticles - chemistry
Norfloxacin
Norfloxacin - chemistry
PLGA
Polymers - chemistry
Silver - chemistry
Silver nanoparticles
Urinary catheter
Urinary Catheterization
Urinary Catheters - microbiology
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Summary:[Display omitted] Bacterial biofilm and crystalline deposits are the common causes of failure of long-term indwelling urinary catheter. Bacteria colonise the catheter surface causing serious infections in the urinary tract and encrustations that can block the catheter and induce trauma in patients. In this study, the strategy used to resist bacterial adhesion and encrustation represents a combination of the antibacterial effects of norfloxacin and silver nanoparticles and the PLGA-based neutralisation of alkali products of urea hydrolysis gained through the degradation of the polymer in an aqueous milieu. Silver nanoparticles were coated with tetraether lipids (TEL) to avoid aggregation when dispersed in acetone and during the film formation. The polymer films loaded with the two antibacterial agents were applied on Polyurethane (PUR) and Silicon sheets. We demonstrated the antibacterial and anti-adhesion effectiveness of the coatings whereby commercially available biocompatible polymers PUR and Silicon were used as controls. Using artificial urine and an in vitro encrustation model, it was shown that the coatings resist the encrustation for at least 2 weeks. This combination of a biodegradable polymer and wide-range antibacterial agents represents a potentially attractive biocompatible coating for urinary catheters.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2017.08.072