The Future Vocation of Neural Stem Cells: Lineage Commitment in Brain Development and Evolution

Understanding the fate commitment of neural stem cells is critical to identify the regulatory mechanisms in developing brains. Genetic lineage-tracing has provided a powerful strategy to unveil the heterogeneous nature of stem cells and their descendants. However, recent studies have reported contro...

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Bibliographic Details
Published in:Neurochemical research 2018, Vol.43 (1), p.162-165
Main Authors: Nomura, Tadashi, Gotoh, Hitoshi, Ono, Katsuhiko
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological evolution
Biomedicine
Brain
Brain - growth & development
Cell Biology
Cell Differentiation - physiology
Cell Lineage - physiology
Heterogeneity
Humans
Neocortex
Neural stem cells
Neural Stem Cells - cytology
Neurochemistry
Neurogenesis - physiology
Neurology
Neurons - cytology
Neurosciences
Original Paper
Regulatory mechanisms (biology)
Stem cell transplantation
Stem cells
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Summary:Understanding the fate commitment of neural stem cells is critical to identify the regulatory mechanisms in developing brains. Genetic lineage-tracing has provided a powerful strategy to unveil the heterogeneous nature of stem cells and their descendants. However, recent studies have reported controversial data regarding the heterogeneity of neural stem cells in the developing mouse neocortex, which prevents a decisive conclusion on this issue. Here, we review the progress that has been made using lineage-tracing analyses of the developing neocortex and discuss stem cell heterogeneity from the viewpoint of comparative and evolutionary biology.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-017-2380-z