Loading…

Fraxitoxin, a New Isochromanone Isolated from Diplodia fraxini

A new isochromanone, named fraxitoxin, was isolated together with (–)‐mellein and tyrosol from liquid cultures of Diplodia fraxini, a pathogen involved in the etiology of canker and dieback disease of Fraxinus spp. in Europe. It was characterized as 5‐methoxy‐3‐methylisochroman‐1‐one using spectrosc...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2017-11, Vol.14 (11), p.n/a
Main Authors: Cimmino, Alessio, Maddau, Lucia, Masi, Marco, Linaldeddu, Benedetto T., Pescitelli, Gennaro, Evidente, Antonio
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new isochromanone, named fraxitoxin, was isolated together with (–)‐mellein and tyrosol from liquid cultures of Diplodia fraxini, a pathogen involved in the etiology of canker and dieback disease of Fraxinus spp. in Europe. It was characterized as 5‐methoxy‐3‐methylisochroman‐1‐one using spectroscopic methods (essentially NMR and HR‐EI‐MS). Its absolute configuration (R) at C(3) was assigned by electronic circular dichroism (ECD) measurements and calculations. Phytotoxic activity of the compound was evaluated on ash, cork and holm oak leaves at concentration of 1 mg/ml by the leaf‐puncture assay. Interestingly, fraxitoxin caused necrotic lesions only on ash leaves.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201700325