Herpesviruses excretion in saliva of pediatric transplant recipients

Background Saliva samples could be used for follow‐up of herpesviruses infection in pediatric transplant recipients. Objective With the aim of determining the frequency of herpesviral infections in saliva samples after transplantation, and the association with viremia and complications, a pilot long...

Full description

Saved in:
Bibliographic Details
Published in:Transplant infectious disease 2017-12, Vol.19 (6), p.n/a
Main Authors: Correa Sierra, Consuelo Beatriz, Kourí Cardellá, Vivian, Pérez Santos, Lissette, Silverio, Cesar E., Hondal, Norma, Florin, Jose
Format: Article
Language:English
Subjects:
CMV
Complications
Cytomegalovirus
Epstein-Barr virus
Excretion
Herpes simplex
herpesviruses
Infections
Liver
Medical treatment
Patients
pediatric transplant recipients
Pediatrics
Polymerase chain reaction
Saliva
solid organ transplantation
Transplantation
Transplants & implants
Varicella
Viremia
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Saliva samples could be used for follow‐up of herpesviruses infection in pediatric transplant recipients. Objective With the aim of determining the frequency of herpesviral infections in saliva samples after transplantation, and the association with viremia and complications, a pilot longitudinal follow‐up of pediatric Cuban transplanted recipients (kidney and liver) was performed. Methods Quantitative real‐time polymerase chain reaction of cytomegalovirus (CMV), Epstein‐Barr virus, herpes simplex virus, human herpesevirus‐6 (HHV6), varicella zoster virus, and human herpesvirus‐8 were serially assayed in saliva and serum samples from 27 transplanted patients, during 32 weeks after the graft. Samples taken immediately after the graft were used as control samples. Results Herpesviruses were detected in 88.9% of saliva and in 37.0% of serum samples. HHV6 and CMV were the viruses more frequently detected (70.4%) in saliva and they were significantly more frequent during the follow‐up in comparison with control samples (P 
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12771