Development of contrast enhancement after long-term observation of a dysembryoplastic neuroepithelial tumor

Dysembryoplastic neuroepithelial tumors (DNET) are usually benign lesions that arise in cortical regions and are discovered after new onset of seizure. These lesions have many different imaging characteristics. We report a patient with a presumed low-grade medial temporal lobe lesion that was follow...

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Bibliographic Details
Published in:Journal of neuro-oncology 2006-05, Vol.78 (1), p.59-62
Main Authors: JENSEN, Randy L, CAAMANO, Eryn, JENSEN, Elizabeth M, COULDWELL, William T
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers, Tumor - analysis
Brain Neoplasms - complications
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Contrast Media
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Development. Senescence. Regeneration. Transplantation
Female
Fundamental and applied biological sciences. Psychology
Gadolinium
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Neoplasms, Neuroepithelial - complications
Neoplasms, Neuroepithelial - metabolism
Neoplasms, Neuroepithelial - pathology
Neurology
Radiographic Image Enhancement
Seizures - etiology
Vertebrates: nervous system and sense organs
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Summary:Dysembryoplastic neuroepithelial tumors (DNET) are usually benign lesions that arise in cortical regions and are discovered after new onset of seizure. These lesions have many different imaging characteristics. We report a patient with a presumed low-grade medial temporal lobe lesion that was followed for many years without any change in size or imaging characteristics. This previously non-enhancing tumor evolved to become contrast enhanced on routine imaging without apparent tumor growth. The patient underwent surgery, and the pathology was confirmed as a DNET with no atypical changes. This case demonstrates the potential that DNETs may exhibit a changing MRI pattern over time. Natural history, imaging characteristics, and management are reviewed.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-005-9054-4