Coronary Artery Disease in Patients With Out-of-Hospital Refractory Ventricular Fibrillation Cardiac Arrest

• Published in: Journal of the American College of Cardiology 2017-08, Vol.70 (9), p.1109-1117
• Main Authors: Yannopoulos, Demetris, Bartos, Jason A., Raveendran, Ganesh, Conterato, Marc, Frascone, Ralph J., Trembley, Alexander, John, Ranjit, Connett, John, Benditt, David G., Lurie, Keith G., Wilson, Robert F., Aufderheide, Tom P.
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Adolescent; Adult; Aged; Angiography; Automation; Cardiac arrest; Cardiac arrhythmia; Cardiology; Cardiopulmonary resuscitation; Cardiopulmonary Resuscitation - methods; Cardiovascular disease; Catheterization; Circulation; Coronary artery; Coronary artery disease; Coronary Artery Disease - epidemiology; Coronary Artery Disease - etiology; Coronary Artery Disease - surgery; Coronary vessels; CPR; Critical care; Emergency medical services; emergent cardiac care; Female; Fibrillation; Heart; Heart diseases; Hospital Mortality - trends; Humans; Implants; Intervention; Intubation; Lesions; Male; Medical imaging; Middle Aged; Nursing homes; Out-of-Hospital Cardiac Arrest - complications; Out-of-Hospital Cardiac Arrest - mortality; Out-of-Hospital Cardiac Arrest - therapy; Patients; Percutaneous Coronary Intervention - methods; Reperfusion; Resuscitation; Retrospective Studies; Stents; sudden cardiac death; Surgical implants; Survival; Survival Rate - trends; Tachycardia; Terminal illnesses; United States - epidemiology; Ventricle; Ventricular fibrillation; Ventricular Fibrillation - complications; Ventricular Fibrillation - mortality; Young Adult
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2017.06.059

The prevalence of coronary artery disease (CAD) among patients with refractory out-of-hospital (OH) ventricular fibrillation (VF)/ventricular tachycardia (VT) cardiac arrest is unknown. The goal of this study was to describe the prevalence and complexity of CAD and report survival to hospital discharge in patients experiencing refractory VF/VT cardiac arrest treated with a novel protocol of early transport to a cardiac catheterization laboratory (CCL) for extracorporeal life support (ECLS) and revascularization. Between December 1, 2015, and December 1, 2016, consecutive adult patients with refractory OH VF/VT cardiac arrest requiring ongoing cardiopulmonary resuscitation were transported by emergency medical services to the CCL. ECLS, coronary angiography, and percutaneous coronary intervention were performed, as appropriate. Functionally favorable survival to hospital discharge (Cerebral Performance Category 1 or 2) was determined. Outcomes in a historical comparison group were also evaluated. Sixty-two (86%) of 72 transported patients met emergency medical services transport criteria. Fifty-five (89%) of the 62 patients met criteria for continuing resuscitation on CCL arrival; 5 had return of spontaneous circulation, 50 received ECLS, and all 55 received coronary angiography. Forty-six (84%) of 55 patients had significant CAD, 35 (64%) of 55 had acute thrombotic lesions, and 46 (84%) of 55 had percutaneous coronary intervention with 2.7 ± 2.0 stents deployed per patient. The mean SYNTAX score was 29.4 ± 13.9. Twenty-six (42%) of 62 patients were discharged alive with Cerebral Performance Category 1 or 2 versus 26 (15.3%) of 170 in the historical comparison group (odds ratio: 4.0; 95% confidence interval: 2.08 to 7.7; p < 0.0001). Complex but treatable CAD was prevalent in patients with refractory OH VF/VT cardiac arrest who also met criteria for continuing resuscitation in the CCL. A systems approach using ECLS and reperfusion seemed to improve functionally favorable survival. [Display omitted]