Time-of-flight ion mobility spectrometry in combination with laser-induced fluorescence detection system

A laser-induced fluorescence (LIF) was used as a complimentary detection system for time-of-flight ion mobility spectrometry (TOF-IMS). A LIF detection system is potentially faster than a conventional electrometer detector and can provide additional (to usual for IMS drift time) analytical informati...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2017-11, Vol.409 (27), p.6279-6286
Main Authors: Uteschil, Florian, Kuklya, Andriy, Kerpen, Klaus, Marks, Robert, Telgheder, Ursula
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Drift
Electrospraying
Fluorescence
Fluorescence spectroscopy
Food Science
Ionic mobility
Ionization
Ions
Laboratory Medicine
Laser induced fluorescence
Maxima
Methods
Mobility
Monitoring/Environmental Analysis
Rapid Communication
Rhodamine 6G
Scientific imaging
Spectrometry
Spectroscopy
Time-of-flight mass spectrometry
Xanthene
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Summary:A laser-induced fluorescence (LIF) was used as a complimentary detection system for time-of-flight ion mobility spectrometry (TOF-IMS). A LIF detection system is potentially faster than a conventional electrometer detector and can provide additional (to usual for IMS drift time) analytical information, namely wavelength of fluorescence maxima and fluorescence lifetime. Therefore, better discrimination ability can be expected. Additionally, the combination of IMS and LIF operates at atmospheric pressure. This allows fluorescence measurements of specified ions and ion clusters, which would not survive in a mass spectrometer. An IMS drift cell of open design with both the electrometer and LIF detectors was designed. The feasibility of IMS-LIF was demonstrated on the example of the Xanthene dye Rhodamine 6G (R6G). Electrospray was used as an ionization source. The release and desolvation of R6G ions from the electrospray with following IMS-LIF analysis were demonstrated. The effects of experimental parameters (e.g., ion gate and drift voltages, distance to ESI emitter) are demonstrated and discussed. The obtained results are promising enough to ensure the potential of LIF as a complimentary/alternative detection system for time-of-flight ion mobility spectrometry.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-017-0584-3