Case Study: Rare Case of Mantle Cell Lymphoma With Extranodal Involvement in the Foot

Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma that commonly affects extranodal sites. The most commonly affected sites are the bone marrow, gastrointestinal tract, Waldeyer's ring, lung, and pleura. We report the case of an 80-year-old diabetic male, in MCL remission, who pr...

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Bibliographic Details
Published in:The Journal of foot and ankle surgery 2017-09, Vol.56 (5), p.1104-1108
Main Authors: Fu, Pauline, Mercado, Danielle, Malezhik, Vera, Mannan, Abul Ala Syed Rifat
Format: Article
Language:English
Subjects:
Aged, 80 and over
cancer
Diabetic Foot - diagnosis
Diabetic Foot - pathology
Diagnosis, Differential
Disease Progression
Foot - pathology
Humans
lymphoma in foot
Lymphoma, Mantle-Cell - diagnosis
Lymphoma, Mantle-Cell - pathology
Lymphoma, Mantle-Cell - surgery
Male
mantle cell lymphoma
Neoplasm Invasiveness - pathology
Neoplasm Staging
Rare Diseases
Risk Assessment
skin involvement
Skin Neoplasms - diagnosis
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Treatment Outcome
tumor
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Summary:Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma that commonly affects extranodal sites. The most commonly affected sites are the bone marrow, gastrointestinal tract, Waldeyer's ring, lung, and pleura. We report the case of an 80-year-old diabetic male, in MCL remission, who presented with a small dome-shaped nodule on his calf and an ipsilateral second digit non-healing ulceration after a traumatic fall. Despite surgical and conservative treatment, the wound worsened, resulting in histopathologic examination, which confirmed the presence of lymphocytes, indicating MCL relapse. This case was followed up for approximately 3 months until the patient died. Our case is an example of pedal manifestations of skin involvement of MCL, which, on consideration of the clinical manifestations also, can be confused with a nonhealing diabetic wound. The clinical significance of our case study is to assist in the diagnosis, management, and prognosis of a patient with MCL.
ISSN:1067-2516
1542-2224
DOI:10.1053/j.jfas.2017.04.019